Results 151 to 160 of about 172,313 (331)

Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone

open access: yesAngewandte Chemie, EarlyView.
A catalytic enantioselective one‐pot “self‐assembly” strategy was developed for the exceedingly convenient access to a spiro bisindole directly from indole and acetone. The obtained enantiopure C2‐symmetric bisindole showed exceptional performance as a chiral backbone of diverse effective catalysts or ligands. Abstract Disclosed here is a “one‐pot self‐
Jing‐Yi Wang   +3 more
wiley   +2 more sources

Mechanochemistry‐Driven Borrowing Hydrogen Processes for Ru‐Catalyzed N‐Alkylation: A Pathway to Enhanced Sustainability and Efficiency

open access: yesAngewandte Chemie, EarlyView.
This work pioneers a solvent‐free mechanochemical borrowing hydrogen (BH) strategy for the rapid and efficient N‐alkylation of amines and heterocycles. By removing harsh conditions and toxic reagents while employing a simple Ru catalyst, this approach redefines BH as a cleaner, more versatile, and sustainable platform for synthetic chemistry.
Sourav Behera   +5 more
wiley   +2 more sources

Iridium‐Catalyzed Enantioselective Intramolecular Hydroarylation of Allenes: Formal Synthesis of (+)‐Rhazinilam

open access: yesAngewandte Chemie, EarlyView.
A highly enantioselective iridium‐catalyzed hydroarylation of allene‐tethered pyrroles and indoles that provides access to relevant heterocyclic systems bearing vinyl‐substituted 3ry or 4ry stereocenters is reported. Its synthetic potential was exemplified with a very short, highly enantioselective formal synthesis of (+)‐Rhazinilam, whereas DFT ...
Andrés Arribas   +4 more
wiley   +2 more sources

Augmented indoles

open access: yesARKIVOC, 2006
David StC. Black   +7 more
doaj   +1 more source

Rapid Methylation of Aryl Bromides Using Air‐Stable DABCO‐Bis(Trimethylaluminum) via Nickel Metallaphotoredox Catalysis

open access: yesAngewandte Chemie, EarlyView.
Herein, we report the use of bis(trimethylaluminum)‐1,4‐diazabicyclo[2.2.2]octane (DABAl‐Me3) as practical source of radicals for the introduction of valuable methyl groups to aryl bromides via a Nickel/metallaphotocatalytic cross coupling strategy.
Jonas Djossou   +8 more
wiley   +2 more sources

Nickel‐Catalyzed Suzuki–Miyaura Cross‐Coupling Reaction of Aliphatic Alcohol Derivatives

open access: yesAngewandte Chemie, EarlyView.
A nickel‐catalyzed Suzuki–Miyaura coupling reaction of aliphatic mesylates is reported. This reaction provides a strategy for late‐stage functionalization of bioactive compounds that have high F(sp3). Preliminary mechanistic experiments confirm a stereoablative reaction outcome, consistent with alkyl radical intermediates.
Chloe D. Wong   +3 more
wiley   +2 more sources

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