Results 61 to 70 of about 172,313 (331)

Visible Light‐Promoted Esterification of Carboxylic Acids via Photoacid Generation Catalysis

Advanced Synthesis &Catalysis, EarlyView.
A novel, environmentally friendly photochemical method for the esterification of carboxylic acids with alcohols using arylazo sulfones as photoacid generators was developed. This approach avoids traditional acidic catalysts, purification did not require chromatography and the method proved effective under continuous flow conditions for enhanced ...
Valentina Benazzi, Periklis X. Kolagkis, Lorenzo di Terlizzi, Eirini M. Galathri, Olga G. Mountanea, Maurizio Fagnoni, Stefano Protti, Christoforos G. Kokotos   +7 more
wiley   +1 more source

Gut Microbiota and Cardiovascular Uremic Toxicities

Toxins, 2018
Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in patients with chronic kidney disease (CKD). Numerous CVD risk factors in CKD patients have been described, but these do not fully explain the high pervasiveness of CVD ...
Manuel T. Velasquez, Patricia Centron, Ian Barrows, Rama Dwivedi, Dominic S. Raj   +4 more
doaj   +1 more source

Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates [PDF]

Royal Society Open Science, 2018
A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N,N-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant.
Xiaojun Luo, Qiang Liu, Hongxia Zhu, Huoji Chen   +3 more
doaj   +1 more source

Photochemical Preparation of (Aza−)Indolines: Diastereoselective Synthesis and Polarity Reversal Strategy

Advanced Synthesis &Catalysis, EarlyView.
Abstract Herein, we present the first light‐mediated, diastereoselective de novo synthesis for 2,3‐substituted indolines, a privileged scaffold in pharmaceuticals. The protocol was tested with various aryl and alkyl groups, maintaining high yields up to 85% across different substituents.
Julian J. Melder, Maxi L. Heldner, Julia Svetličić, Abdinasir Adow, Frank Rominger, Matthias Rudolph, Günter Helmchen, A. Stephen K. Hashmi   +7 more
wiley   +1 more source

Nickel(II)-Catalyzed Formal [3+2] Cycloadditions between Indoles and Donor–Acceptor Cyclopropanes

Molecules
This article describes the development of a nickel-catalyzed regio- and diastereoselective formal [3+2] cycloaddition between N-substituted indoles and donor–acceptor cyclopropanes to synthesize cyclopenta[b]indoles. Optimized reaction conditions provide
Víctor Quezada, Mariña Castroagudín, Felipe Verdugo, Sergio Ortiz, Guillermo Zaragoza, Fabiane M. Nachtigall, Francisco A. A. Reis, Alejandro Castro-Alvarez, Leonardo S. Santos, Ronald Nelson   +9 more
doaj   +1 more source

The Indole Pulse: A New Perspective on Indole Signalling in Escherichia coli

PLoS ONE, 2014
Indole has diverse signalling roles, including modulation of biofilm formation, virulence and stress responses. Changes are induced by indole concentrations of 0.5-1.0 mM, similar to those found in the supernatant of Escherichia coli stationary phase culture.
Hannah Gaimster, Jehangir Cama, Silvia Hernández-Ainsa, Ulrich F. Keyser, David K. Summers   +4 more
openaire   +8 more sources

eAmidation: An Electrochemical Amidation of Aldehydes via the Oxidation of N‐Aryl Hydrazones

Advanced Synthesis &Catalysis, EarlyView.
The indirect electrochemical oxidation of N‐aryl hydrazones offers an efficient approach to access amides from aldehydes and amines. The AZADO‐mediated reaction enables the selective synthesis of a broad range of valuable amides using readily available aldehydes.
Luke Chen, James David Francis Thompson, Craig Jamieson   +2 more
wiley   +1 more source

Palladium-catalyzed regio- and stereoselective synthesis of aryl and 3-indolyl-substituted 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones

Beilstein Journal of Organic Chemistry, 2020
Cascade cyclocarbopalladation of the readily available aryl/alkyl-substituted propargylic amides containing an aryl iodide moiety, followed by Suzuki–Miyaura coupling with arylboronic acids, allowed an efficient regio- and stereoselective synthesis of ...
Valeria Nori, Antonio Arcadi, Armando Carlone, Fabio Marinelli, Marco Chiarini   +4 more
doaj   +1 more source

5-MeO-DALT: the freebase of N,N-diallyl-5-methoxytryptamine

IUCrData, 2020
The title compound {systematic name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-(prop-2-en-1-yl)prop-2-en-1-amine), C17H22N2O, has a single tryptamine molecule in the asymmetric unit.
Andrew R. Chadeayne, Duyen N. K. Pham, James A. Golen, David R. Manke   +3 more
doaj   +1 more source

Integrating Visible‐Light Photocatalysis and Enzymes for the Stereoselective Synthesis of Alcohols and Amines

Advanced Synthesis &Catalysis, EarlyView.
The integration between visible‐light photocatalysis and biocatalysis has the potential to greatly improve modern organic synthesis by combining the production of valuable synthetic intermediates under mild photochemical conditions with the high degree of stereoselectivity reached by enzymes. The review collects the recent efforts in the photoenzymatic
Stefano Parisotto, Cristina Prandi
wiley   +1 more source