Results 21 to 30 of about 90,075 (209)
Asymmetric Total Synthesis of the Indole Diterpene Alkaloid Paspaline [PDF]
The Journal of Organic Chemistry, 2015 An enantioselective synthesis of the indole diterpenoid natural product paspaline is disclosed. Critical to this approach was the implementation of stereoselective desymmetrization reactions to assemble key stereocenters of the molecule. The design and execution of these tactics are described in detail, and a thorough analysis of observed outcomes is ...
Robert J, Sharpe, Jeffrey S, Johnson
openaire +2 more sources
Synthesis of pyrrolobenzothiadiazepines, pyrrolizidines and indoles [PDF]
In this thesis, novel syntheses of analogues of pyrrolobenzodiazepines (PBDs) are described. These compounds are of great interest as synthetic targets due to their potential medical properties.
Joãoa, Heidi
core +3 more sources
A Fischer Indolization Strategy toward the Total Synthesis of (–)-Goniomitine [PDF]
HETEROCYCLES, 2017 A Fischer indolization strategy toward the core of (-)-goniomitine is reported. Initial investigations into the Pd-catalyzed asymmetric allylic alkylation of dihydropyrido[1,2-a]indolone (DHPI) substrates are also discussed.
Pritchett, Beau P. +3 more
openaire +4 more sources
Total synthesis of the tetracyclic indole alkaloid ht-13-A [PDF]
Tetrahedron Letters, 2015 An expedient synthesis corroborating the proposed structure of the tetracyclic indole alkaloid ht-13-B is presented. Key synthetic steps include acyliminium ion allylation, a Mitsunobu reaction, a palladium-catalyzed Stille-Kelly cross coupling reaction, and a carbon monoxide-mediated palladium-catalyzed reductive N-heterocyclization.
Yilin, Zhang +4 more
openaire +2 more sources
Total Synthesis of the Chlorinated Pentacyclic Indole Alkaloid (+)-Ambiguine G [PDF]
Journal of the American Chemical Society, 2021 Reported herein is the total synthesis of (+)-ambiguine G, the first member of the chlorinated pentacyclic ambiguines to yield to chemical synthesis. The synthesis is accomplished through a convergent strategy that proceeds in 10 steps from (S)-carvone oxide.
Hu, Lingbowei, Rawal, Viresh H.
openaire +3 more sources
Total Synthesis of the Proposed Structures of Indole Alkaloids Lyaline and Lyadine [PDF]
The Journal of Organic Chemistry, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
M-Lluïsa, Bennasar +2 more
openaire +2 more sources
, 2022 Chemodivergent synthesis of indeno[1,2-b]indoles and isoindolo[2,1-a]indoles from the same starting materials involving radical cross-dehydrogenative couplings have been developed. Mn(OAc)3·2H2O selectively promoted an intramolecular radical C–H/C–H
Piao Lu (13171134) +7 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source