Results 91 to 100 of about 46,494 (229)
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat
Advanced Science, Volume 13, Issue 31, 4 June 2026.An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su +10 more
wiley +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo +6 more
wiley +1 more source
Advanced Science, Volume 13, Issue 31, 4 June 2026.We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng +8 more
wiley +1 more source
ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy
Advanced Science, Volume 13, Issue 36, 29 June 2026.A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 36, 29 June 2026.We developed a series of quinoxalinoquinoxaline (QQ) photosensitizers featuring high and tunable excited‐state reduction potentials (E(PC•+/PC*) = –1.76 to –2.05 V vs. SCE). Their hydrogen‐bonding interaction with carbonyl substrates enables selective single‐electron transfer events for selective nitrilization of 1° amides, offering a tunable ...
Seongwoo Bae, Dongwook Kim, Jinwoo Kim
wiley +1 more source
Aggregate, Volume 7, Issue 6, June 2026.This review explores the application of machine learning‐based image analysis technology in four major organic crystallization tasks, providing a reference for subsequent research in the corresponding fields. ABSTRACT Manual crystallization experiments have always been challenging, requiring extensive process development expertise and often resulting ...
Tianqi Ma +8 more
wiley +1 more source
Indomethacin: Studies of Absorption and of the Use of Indomethacin Suppositories [PDF]
BMJ, 1965 L P, HOLT, C F, HAWKINS
openaire +2 more sources
Analytical Science Advances, Volume 7, Issue 1, June 2026.Zanha golungensis contains phenolic compounds amongst which are two previously undescribed flavonoid glycosides as shown in this study. The constituents of this plant exhibit anti‐inflammatory activity by inhibiting cyclooxygenases (COX‐1 and COX‐2).
Jean Zeuikena +7 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.Essential oil from Thymelaea tartonraira was characterized by GC–MS and evaluated using in vitro and in silico approaches. The oil exhibited notable antiplatelet activity with low cytotoxicity. Molecular docking revealed strong interactions of major compounds with GPVI, COX‐1, and P2Y12, supporting its potential as a natural antiplatelet agent ...
Siwar Soltani +8 more
wiley +1 more source