Results 71 to 80 of about 46,561 (203)

Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain

Neurobiology of Disease, 2015
Intracellular zinc overload causes neuronal injury during the course of neurological disorders, whereas mild levels of zinc are beneficial to neurons.
Joo-Yong Lee, Shin Bi Oh, Jung-Jin Hwang, Nayoung Suh, Dong-Gyu Jo, Jong S. Kim, Jae-Young Koh   +6 more
doaj   +1 more source

3D Bioprinted Breast Cancer‐Stroma Model with Tailored Migration‐Permissive Bioink Reveals Impact of Adipose‐Derived Stromal Cells on Cancer Cell Migration and Invasion Dynamics

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
A migration‐permissive bioink composed of methacrylated collagen type I and thiolated hyaluronic acid enables 3D bioprinting of breast cancer‐stroma models. Single‐cell tracking reveals that adipose stromal cells enhance tumor cell motility and stromal invasion, accompanied by collagen remodeling, and a shift in tumor cell morphology.
Sabrina Stecher, Joachim Schenk, Alessandro Cianciosi, Katherina Hemmen, David Böhringer, Franziska Dusi, Jessica Faber, Philipp Stahlhut, Benedikt Gantert, Emilie Rouenhoff, Annika Gmöhling, Tessa Lühmann, Jörg Teßmar, Jürgen Groll, Silvia Budday, Tomasz Jüngst, Ben Fabry, Katrin G. Heinze, Petra Bauer‐Kreisel, Torsten Blunk   +19 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Is oral indomethacin effective in treatment of preterm infants with patent ductus arteriosus?

The Turkish Journal of Pediatrics, 2004
Twenty-one preterm infants (with a mean gestational age and birth weight of 29.3 weeks and 1288.6 g) and nine pretem infants (with a mean gestational age and birth weight of 29.6 weeks and 1153.1 g) were treated with an enteral preparation of ...
Mehmet Satar, Hacer Yapicioğlu, Nejat Narli, Nazan Ozbarlas, Osman Küçükosmanoğlu, Ercan Tutak   +5 more
doaj  

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2764-2776, August 2026.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Calvarial Metastasis of Breast Carcinoma Manifesting as a New Daily Persistent Headache: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT New‐onset daily persistent headache (NDPH) is a primary headache syndrome characterized by a sudden onset of daily headaches persisting for more than three months in patients with no prior headache history. We report the case of a 49‐year‐old Indian lady who presented to the neurology outpatient clinic with new daily persistent headache.
Neha Lall, Anand Kumar, Deepika Joshi, Pramod Kumar Singh   +3 more
wiley   +1 more source

Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai, Mengchen Ma, Yuqin Zhu, Mengru Shi, Xiaoyan Dai, Yujie Wang, Mengru Li, Yanwen Yu, Yajiao Wang, Liang Xu   +9 more
wiley   +1 more source

The Impact of Oral‐Gut Microbiota Structure and Its Manipulation on RA Development and Management

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
(A) Schematic representation of oral–gut microbiota composition in health and rheumatoid arthritis (RA), highlighting the enrichment of beneficial microorganisms (green) under healthy conditions and the expansion of pathogenic microorganisms (orange) in RA‐associated dysbiosis.
Parisa Ahmadi, Mahmoud Mahmoudi, Sina Mozaffari‐Jovin, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Jafar Hajavi, Hanieh Kolahdooz, Seyed‐Alireza Esmaeili   +8 more
wiley   +1 more source

Prevention of Indomethacin - Induced Gastric Ulcers in Rats by Extract from Leaves of Centella asiatica

Siriraj Medical Journal, 2007
Objective: The aim of this study is to investigate the protective effect of Centella asiatica extract on gastric ulcers caused by indomethacin in rats.
Kittisak Sripanidkulchai, Nawaporn Techataweewan, Bungorn Sripanidkulchai   +2 more
doaj  

Effect of Atorvastatin on Indomethacin-Induced Gastric Ulceration in Rats: Role of Nitric Oxide and Gastric Motility

Medical Journal of Babylon
Background: Non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastric ulceration caused by inhibition of prostaglandins. Atorvastatin, a widely used hypolipidemic agent, has many beneficial pleiotropic effects like anti-inflammatory and antioxidant ...
Dilgash A. Ali, Hani M. Almukhtar
doaj   +1 more source