Results 61 to 70 of about 68,039 (253)

Biopharmaceutical evaluation of oral controlled indomethacin delivery systems based on drug-polymer and drug-interpolyelectrolyte complexes

Разработка и регистрация лекарственных средств
Introduction. Interpolyelectrolyte complexes (IPEC) are promising carriers for controlled drug delivery systems. The introduction of ionic API into delivery systems can lead to the formation of bonds with polyelectrolytes, which affects the release of ...
A. Yu. Sitenkov, A. V. Sitenkova (Bukhovets), S. F. Nasibullin, I. I. Semina, R. I. Moustafine   +4 more
doaj   +1 more source

Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits

, 1991
The effects of indomethacin on central nervous system abnormalities in rabbits with experimental pneumococcal meningitis were studied. As expected, prostaglandin E2 levels in cerebrospinal fluid were significantly lower in the indomethacin-treated group,
M. G. Tauber,, J. H. Tureen, M. A. Sande, Täuber, MG, Tureen, JH, Sande, MA   +5 more
core   +1 more source

Network meta‐analysis of tocolytics in preterm labor: Establishing an evidence‐based treatment hierarchy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background The choice of tocolytic drugs is one of the most debated aspects of preterm birth management. Objective This network meta‐analysis aimed to establish an evidence‐based hierarchy for tocolytics used in preterm labor by evaluating their efficacy in delaying delivery, safety, and neonatal outcomes.
Barbara Gardella, Chiara Cassani, Vittoria Morteo, Alessandra Marmiroli, Mattia Dominoni, Arsenio Spinillo   +5 more
wiley   +1 more source

In vitro and in vivo assessment of indomethacin-induced genotoxicity: protection by curcumin

Research in Pharmaceutical Sciences
Background and purpose: Indomethacin is one of the most widely used non-steroidal anti-inflammatory drugs. This study aimed to investigate the protective effects of curcumin against indomethacin-induced genotoxicity.
Ehsan Zamani, Reza Alipour Klour, Amirreza Gholami Shekarsarayi, Foad Ghazizadeh, Mehdi Evazalipour   +4 more
doaj   +1 more source

Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis

Gastroenterology Research and Practice, 2018
Background and Aim. Rectal indomethacin was reported to be effective for postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) prophylaxis.
Xingkang He, Wenfang Zheng, Yue Ding, Xia Tang, Jianmin Si, Lei-min Sun   +5 more
doaj   +1 more source

Dose‐Related Gastric Toxicity of Diethyl Phthalate in Female Wistar Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diethyl phthalate (DEP) is commonly used in cosmetics, personal care products, and pharmaceutical formulations as a low‐molecular‐weight phthalate. Despite its widespread use, information on its effects on the gastric mucosa remains limited. This study examined the dose‐related effects of DEP on inflammation, oxidative stress, gastric mucosal ...
Gul Sahika Gokdemir, Mehmet Cihan Yavaş, Selim Demirtaş, Fazile Cantürk Tan, Salih Varol, Mehmet Tahir Gokdemir   +5 more
wiley   +1 more source

Exposure of Human Breast Cancer Cells to the Anti-inflammatory Agent Indomethacin Alters Choline Phospholipid Metabolites and Nm23 Expression

Neoplasia: An International Journal for Oncology Research, 2002
We previously observed that changes in choline phospholipids of two malignant human mammary epithelial cells. (HMECs) following treatment with a high dose of the cyclooxygenase.
Kshama Natarajan, Noriko Mori, Dmitri Artemov, Zaver M. Bhujwalla   +3 more
doaj   +1 more source

Comparison of the effects of indomethacin, diclofenac and acetaminophen suppositories on pain score and pethedine usage after cesarean section [PDF]

Background : Cesarean section is one of the common surgeries of women. The rate of cesarean section over the west societies is currently about 14%-15%. In Iran the rate of cesarean section is higher than universal statistics. Acute postoperative pain is
اخوان اکبری, قدرت, عیسی زاده فر, خاطره, انتظاری, مسعود   +2 more
core  

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Effectiveness of indomethacin in preventing Heterotopic Ossification: a systematic review and meta-analysis of randomized controlled trials

Journal of Orthopaedic Surgery and Research
Background Heterotopic ossification (HO) is a frequent complication of joint trauma or surgery, commonly occurring after hip replacements, acetabular or other joint injuries, or surgeries.
Lei Wen, Changshun Chen, Yongcheng Deng, Ge Chen   +3 more
doaj   +1 more source