Results 31 to 40 of about 46,494 (229)

Preparation of Prodrug from Indomethacine and Ascorbic acid and study of It's Effect on Asparatate amino transferase Enzyme Partially Purified from Blood of Diabetic Patients Type two. [PDF]

Kirkuk Journal of Science, 2016
The aim of this study is to prepare a new ester prodrug. used for this purpose ascorbic acid vitamin C and indomethacin by esterification reaction, and partial purification of the AST from blood serum with diabetes type II, and we following steps: 1 ...
Amina F. Yahya, Hanaa K. Salih, Firas T. Maher   +2 more
doaj   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

S‐allyl‐L‐cysteine protects hepatocytes from indomethacin‐induced apoptosis by attenuating endoplasmic reticulum stress

FEBS Open Bio, 2020
Drug‐induced liver injury (DILI) can lead to acute liver failure, a lethal condition which may require liver transplantation. Hepatotoxicity associated with nonsteroidal anti‐inflammatory drugs (NSAIDs) accounts for ~ 10% of all DILI.
Peng Chen, Chen Chen, Mingdao Hu, Rui Cui, Feng Liu, Henghai Yu, Yuling Ren   +6 more
doaj   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell death

iScience
Summary: Gastric cancer (GC) is a deadly malignancy that demands effective therapeutic intervention capitalizing unique drug target/s. Here, we report that indomethacin, a cyclooxygenase non-selective non-steroidal anti-inflammatory drug, arrests GC cell
Subhashis Debsharma, Saikat Pramanik, Samik Bindu, Somnath Mazumder, Troyee Das, Uttam Pal, Debanjan Saha, Rudranil De, Shiladitya Nag, Chinmoy Banerjee, Nakul Chandra Maiti, Zhumur Ghosh, Uday Bandyopadhyay   +12 more
doaj   +1 more source

Effect of Aspirin and Indomethacin on Prostaglandin E2 Synthesis in C6 Glioma Cells

Kaohsiung Journal of Medical Sciences, 2004
Prostaglandin E2 (PGE2) plays an important role in immunosuppression and tumor growth. PGE2 inhibitors such as aspirin and indomethacin suppress experimental tumor growth. Little is known of the relationship between PGE2 synthesis in brain tumors and the
Shiuh-Lin Hwang, Kung-Shing Lee, Chih-Lung Lin, Ann-Shung Lieu, Chi-Yun Cheng, Joon-Khim Loh, Yan-Fen Hwang, Yu-Feng Su, Shen-Long Howng   +8 more
doaj   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Paranoid psychosis after a single parenteral dose of indomethacin administered for headache diagnosis: A case and review of the literature

Cephalalgia Reports
Background: Indomethacin is a non-steroidal anti-inflammatory used to diagnose and treat hemicrania continua and paroxysmal hemicrania. Treatment can be complicated by gastrointestinal adverse effects; less commonly reported are idiosyncratic ...
Nazia Karsan, Ray Pyari Bose, Peter J Goadsby   +2 more
doaj   +1 more source

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

Pumpkin Oil–Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats [Retraction]

International Journal of Nanomedicine, 2023
Ahmed OAA, Fahmy UA, Bakhaidar R, et al. Int J Nanomedicine. 2020;15:2529–2539. The Editor and Publisher of International Journal of Nanomedicine are retracting the above published article. An investigation by the Publisher found overlap in images
Ahmed OAA, Fahmy UA, Bakhaidar R, El-Moselhy MA, Alfaleh MA, Ahmed ASF, Hammad ASA, Aldawsari H, Alhakamy NA   +8 more
doaj