Results 11 to 20 of about 46,561 (203)

Tacrolimus (FK506), an Immunosuppressive Agent, Prevents Indomethacin-Induced Small Intestinal Ulceration in the Rat: Inhibition of Inducible Nitric Oxide Synthase Expression

Journal of Pharmacological Sciences, 2007
We examined the effect of tacrolimus (FK506), an immunosuppressive drug, on indomethacin-induced small intestinal ulceration in rats. Animals were given indomethacin (10 mg/kg, s.c.), killed 24 h later, and myeloperoxidase (MPO) activity and ...
Shinichi Kato, Hikaru Nishio, Michitaka Ogura, Koji Takeuchi   +3 more
doaj   +1 more source

Development of Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Indomethacin Disposition in Pregnancy. [PDF]

PLoS ONE, 2015
Findings of a recent clinical study showed indomethacin has lower plasma levels and higher steady-state apparent clearance in pregnant subjects when compared to those in non-pregnant subjects reported in separate studies.
Saeed Alqahtani, Amal Kaddoumi
doaj   +1 more source

Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes

Angewandte Chemie, EarlyView.
A strategy for accelerated photochemical reaction discovery is reported that harnesses the dynamic speciation of copper complexes, driven by their labile metal–ligand bonds. This platform simplifies reaction screening by combining an earth‐abundant copper(II) salt with commercially available ligands, which reversibly generate multiple catalytic species
Alessio Regni, Siyu Liang, Supreeta Sen, Hailey Hendricks, Xijue Wu, Matthew V. Pecoraro, Jose B. Roque   +6 more
wiley   +2 more sources

Feasibility of a High-Dose Inhaled Indomethacin Dry Powder with Dual Deposition for Pulmonary and Oral Delivery

Pharmaceutics
In this study we have developed a high-dose dry powder inhaler formulation of indomethacin using a novel approach to carrier-based formulations. Specifically, larger drug particles serve as the carrier for the smaller micronized drug particles, such that
Jamie E. Spahn, Amr Hefnawy, Feng Zhang, Hugh D. C. Smyth   +3 more
doaj   +1 more source

Liver Response to Indomethacin-Induced Intestinal Injury

Acta Medica, 2002
The aim of our study was to evaluate the impact of impaired barrier function of the small intestine induced by indomethacin on biochemical markers of liver damage (serum levels of alanine aminotransferase, aspartate aminotransferase, bilirubin), and ...
Zuzana Červinková, Dagmar Radvaková, Pavel Kohout   +2 more
doaj   +1 more source

Comparative Study of Garlic and Silver Nanoparticles Protective Role in Indomethacin-Induced Gastric Damage in Adult Male Albino Rats (light and scanning electron microscopy studies)

The Egyptian Journal of Histology
Background: Indomethacin, a commonly used NSAID (non-steroidal anti-inflammatory drug), can induce gastric ulceration. Garlic has shown protective antioxidant effects against indomethacin induced gastric ulceration due to its ability to scavenge free ...
Nesma Elgohary, Abeer Mohamed, Ereny Youssif, Lamiaa Farghaly, somaya Mahmoud   +4 more
doaj   +1 more source

The Effect of Tarantula Cubensis Alcoholic Extract Against Indomethacin-Induced Oxidative Liver and Kidney Damage in Albino Rats.

Pharmata
Objective: The aim of this study was to determine the effects of a single dose of indomethacin on the oxidant and antioxidant systems of the liver and kidneys and to determine whether the alcoholic extract of Tarantula Cubensis has a protective role ...
Ufuk Mercan Yücel
doaj   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

HETEROTOPIC OSSIFICATION IN ACETABULAR FRACTURES: SYSTEMATIC REVIEW AND META-ANALYSIS OF PROPHYLAXIS

Acta Ortopédica Brasileira, 2021
Objective: Heterotopic ossification is defined as the formation of trabecular bone in soft tissues. It is a common complication after surgical treatment of acetabular fractures. However, its prophylaxis and treatment are still controversial.
THIAGO SANCHEZ PIRES BUENO, GABRIEL PARIS DE GODOY, REBECA BARROS FURUKAVA, NICOLE TAKAKURA GAGGIOLI, MARCEL JUN SUGAWARA TAMAOKI, FABIO TERUO MATSUNAGA, JOÃO CARLOS BELLOTI   +6 more
doaj   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source