Liver Response to Indomethacin-Induced Intestinal Injury
Acta Medica, 2002 The aim of our study was to evaluate the impact of impaired barrier function of the small intestine induced by indomethacin on biochemical markers of liver damage (serum levels of alanine aminotransferase, aspartate aminotransferase, bilirubin), and ...
Zuzana Červinková +2 more
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Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
Clinical Pharmacology: Advances and Applications, 2014 Gian Maria Pacifici Medical School, Department of Translational Research and New Technologies in Medicine and Surgery, Section of Pharmacology, University of Pisa, Pisa, Italy Objective: The objective of this study was to evaluate the extent of renal ...
Pacifici GM
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Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease [PDF]
, 1993 There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients.
Niemeyer, A. +8 more
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A 47-year-old misunderstanding: Indomethacin Polymorph δ revealed to be two plastically bendable crystal forms by 3D electron diffraction [PDF]
, 2021 Indomethacin is a clinically classical non-steroidal anti-inflammatory drug that has been marketed since 1965. The third polymorph, Form δ, was discovered by both melt and solution crystallization in 1974.
Shuting , Li +5 more
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Triboelectrification and dissolution property enhancements of solid dispersions [PDF]
, 2015 The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles.
Conway, Barbara R +12 more
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Journal of Pharmacological Sciences, 2007 We examined the effect of tacrolimus (FK506), an immunosuppressive drug, on indomethacin-induced small intestinal ulceration in rats. Animals were given indomethacin (10 mg/kg, s.c.), killed 24 h later, and myeloperoxidase (MPO) activity and ...
Shinichi Kato +3 more
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Development of Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Indomethacin Disposition in Pregnancy. [PDF]
PLoS ONE, 2015 Findings of a recent clinical study showed indomethacin has lower plasma levels and higher steady-state apparent clearance in pregnant subjects when compared to those in non-pregnant subjects reported in separate studies.
Saeed Alqahtani, Amal Kaddoumi
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Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein [PDF]
, 2008 Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD).
Hermann Esselmann +17 more
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Angewandte Chemie, EarlyView.Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang +1 more
wiley +2 more sources
The formulation and evaluation of indomethacin tablets [PDF]
, 1998 Magister Pharmaceuticae - MPharmThe overall objective of this research is to attempt to produce, by direct compression, indomethacin tablets which have good dissolution characteristics and an improved bioavailability profile, when compared to the ...
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