Results 21 to 30 of about 68,039 (253)

A de‐novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly‐Controlled Kinetic Electron Transfer Gating

Angewandte Chemie, EarlyView.
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha, Rajesh Kancherla, Jorge Escorihuela, Shana Chandran, Mrinal K. Bera, Magnus Rueping, Burkhard König   +6 more
wiley   +2 more sources

Generation of a neonatal sepsis model in humanized mice [PDF]

, 2012
Streptococcus agalactiae (group B streptococcus (GBS)) is a gram-positive bacterium and a harmless commensal in the gastrointestinal and vaginal flora of healthy adults.
Ernst, Wolfgang
core   +1 more source

Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes

Angewandte Chemie, EarlyView.
A strategy for accelerated photochemical reaction discovery is reported that harnesses the dynamic speciation of copper complexes, driven by their labile metal–ligand bonds. This platform simplifies reaction screening by combining an earth‐abundant copper(II) salt with commercially available ligands, which reversibly generate multiple catalytic species
Alessio Regni, Siyu Liang, Supreeta Sen, Hailey Hendricks, Xijue Wu, Matthew V. Pecoraro, Jose B. Roque   +6 more
wiley   +2 more sources

Feasibility of a High-Dose Inhaled Indomethacin Dry Powder with Dual Deposition for Pulmonary and Oral Delivery

Pharmaceutics
In this study we have developed a high-dose dry powder inhaler formulation of indomethacin using a novel approach to carrier-based formulations. Specifically, larger drug particles serve as the carrier for the smaller micronized drug particles, such that
Jamie E. Spahn, Amr Hefnawy, Feng Zhang, Hugh D. C. Smyth   +3 more
doaj   +1 more source

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole-Pyrazole Hybrid Scaffolds as Multi-Target Anti-Ulcer Agents. [PDF]

Chem Biodivers
The hybrid pharmacophore approach involves the combination of benzimidazole‐pyrazole moieties to form multi‐functional anti‐ulcer compounds. Molecular modeling and biological evaluations show significant proton pump inhibition, anti‐inflammatory action, antioxidant property, and remarkable prevention of gastric ulcers.
Kharl HAA, Malik A, Nadeem H, Ola MS, Aiman S, Khan AU, Farooq MA, Muzaffar H, Masaud SM.   +8 more
europepmc   +2 more sources

The effects of indomethacin, diclofenac, and acetaminophen suppository on pain and opioids consumption after cesarean section [PDF]

Background: Cesarean section is one of the common surgeries of women. Acute post-operative pain is one of the recognized post-operative complications.
Masood Entezariasl, Fariba Kahnamoyiagdam, اخوان اکبری, قدرت, عیسی زاده فر, خاطره, انتظاری, مسعود, Godrat Akhavanakbari, Khatereh Isazadehfar, کهنمویی, فریبا   +7 more
core   +1 more source

Comparative Study of Garlic and Silver Nanoparticles Protective Role in Indomethacin-Induced Gastric Damage in Adult Male Albino Rats (light and scanning electron microscopy studies)

The Egyptian Journal of Histology
Background: Indomethacin, a commonly used NSAID (non-steroidal anti-inflammatory drug), can induce gastric ulceration. Garlic has shown protective antioxidant effects against indomethacin induced gastric ulceration due to its ability to scavenge free ...
Nesma Elgohary, Abeer Mohamed, Ereny Youssif, Lamiaa Farghaly, somaya Mahmoud   +4 more
doaj   +1 more source

Indomethacin Enhances Brown Fat Activity [PDF]

, 2018
Indomethacin, a nonsteroidal anti-inflammatory drug, has been shown to induce white adipocyte differentiation; however, its roles in brown adipocyte differentiation and activation in brown adipose tissue (BAT) and obesity are unknown.
Hammock, Bruce D, Kodani, Sean D, Zhao, Ling, Wang, Shu, Dayong Wu, Lei Hao, Ling Zhao, Sun, Xiaocun, Sheyenne Scott, Wu, Dayong, Morisseau, Christophe, Jamie Kearns, Hao, Lei, Bruce D. Hammock, Xiaocun Sun, Christophe Morisseau, Hammock, Bruce D., Scott, Sheyenne, Kodani, Sean D., Sean D. Kodani, Shu Wang, Kearns, Jamie   +21 more
core   +1 more source

The Effect of Tarantula Cubensis Alcoholic Extract Against Indomethacin-Induced Oxidative Liver and Kidney Damage in Albino Rats.

Pharmata
Objective: The aim of this study was to determine the effects of a single dose of indomethacin on the oxidant and antioxidant systems of the liver and kidneys and to determine whether the alcoholic extract of Tarantula Cubensis has a protective role ...
Ufuk Mercan Yücel
doaj   +1 more source

HETEROTOPIC OSSIFICATION IN ACETABULAR FRACTURES: SYSTEMATIC REVIEW AND META-ANALYSIS OF PROPHYLAXIS

Acta Ortopédica Brasileira, 2021
Objective: Heterotopic ossification is defined as the formation of trabecular bone in soft tissues. It is a common complication after surgical treatment of acetabular fractures. However, its prophylaxis and treatment are still controversial.
THIAGO SANCHEZ PIRES BUENO, GABRIEL PARIS DE GODOY, REBECA BARROS FURUKAVA, NICOLE TAKAKURA GAGGIOLI, MARCEL JUN SUGAWARA TAMAOKI, FABIO TERUO MATSUNAGA, JOÃO CARLOS BELLOTI   +6 more
doaj   +1 more source