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Sulfation of Indoxyl by Human and Rat Aryl (Phenol) Sulfotransferases to Form Indoxyl Sulfate [PDF]
European Journal of Drug Metabolism and Pharmacokinetics, 2002 The aim of this study was to identify sulfotransferase (SULT) isoform(s) responsible for the formation of indoxyl sulfate from indoxyl (3-hydroxyindole). Indoxyl was incubated together with the co-substrate 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and either human or rat liver cytosol or recombinant sulfotransferase enzymes.
Roberta S. King, Erden Banoğlu
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Indoxyl Sulfate and Atherosclerotic Risk Factors in Hemodialysis Patients
American Journal of Nephrology, 2007<i>Background:</i> Indoxyl sulfate is a uremic toxin that accelerates the progression of chronic kidney disease (CKD). Serum levels of indoxyl sulfate are increased in dialysis patients. It was reported that indoxyl sulfate plays a role in endothelial dysfunction in uremic patients, and stimulates proliferation of rat vascular smooth muscle
Kentaro Taki +2 more
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Indoxyl Sulfate Induces Nephrovascular Senescence
Journal of Renal Nutrition, 2012Indoxyl sulfate is markedly accumulated in the serum of chronic kidney disease (CKD) patients. The oral sorbent AST-120 reduces serum levels of indoxyl sulfate in CKD patients by adsorbing indole, a precursor of indoxyl sulfate, in the intestine. Indoxyl sulfate is taken up by proximal tubular cells through organic anion transporters (OAT1, OAT3), and ...
Toshimitsu, Niwa, Hidehisa, Shimizu
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Growth-Promoting Activity of Potassium Indoxyl Sulfate and Indoxyl Acetate
Botanical Gazette, 19541. In this paper exploratory experiments have been described in which some oxidized indole derivatives have stimulated slightly the growth of corn coleoptile sections. 2. When potassium indoxyl sulfate and indoxyl acetate were supplied, light appeared to modify greatly the growth response. 3. Whether considered as degradation products in the metabolism
Richard C. French, Harry Beevers
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Indoxyl Sulfate and Arteriosclerosis
2020The uremic toxin indoxyl sulfate, metabolized from dietary tryptophan, accumulates in the serum of patients with decreased renal function. A higher level of serum indoxyl sulfate is reported to be an independent risk factor for cardiovascular events and death in patients with chronic kidney disease.
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Indoxyl Sulfate Is a Nephro-Vascular Toxin
Journal of Renal Nutrition, 2010Indoxyl sulfate is markedly accumulated in the serum of patients with chronic kidney disease (CKD). The oral sorbent AST-120 reduces the serum levels of indoxyl sulfate in CKD patients by adsorbing indole, a precursor of indoxyl sulfate, in the intestine, and thereby stimulating its excretion in feces. AST-120 is used for the treatment of patients with
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Performance evaluation of an Indoxyl Sulfate Assay Kit “NIPRO”
Clinical Chemistry and Laboratory Medicine (CCLM), 2019Abstract Background The relationship between renal disease and cardiovascular disease (CVD) is currently known as cardiorenal syndrome. Indoxyl sulfate (IS) is one of the uremic toxins that accelerates the progression of cardiorenal syndrome.
Yuki, Fushimi +5 more
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Effect of uremic toxin-indoxyl sulfate on the skeletal system
Clinica Chimica Acta, 2018Chronic kidney disease-mineral bone disorders (CKD-MBD) exhibit abnormalities in the circulating mineral levels, vitamin D metabolism, and parathyroid function that contribute to the formation of a bone lesion. The uremic toxin, indoxyl sulfate (IS), accumulates in the blood in cases of renal failure and leads to bone loss. The bone and renal responses
Wen-Chih, Liu +8 more
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Engineered binding sites for indoxyl sulfate and p-cresol sulfate
2023The removal of uremic toxins is of great importance in preventing the progression of chronic kidney disease. The investigation of the interaction of uremic toxins with serum and dialysis materials will contribute to the advancement of techniques in uremic toxins removal.
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The influence of indoxyl sulfate and ammonium on the autofluorescence of human urine
Talanta, 2010Despite biological variability the spectral characteristics of undiluted human urine show relatively low autofluorescence at short UV (250-300nm) excitation. However with dilution the fluorescence intensity remarkably increases. This paper examines the mechanisms behind this effect, by using excitation-emission matrices.
Sandeep Menon, Perinchery +3 more
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