Results 101 to 110 of about 1,816,039 (262)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
npj Systems Biology and ApplicationsBreast cancer is one of the prevailing cancers globally, with a high mortality rate. Metastatic breast cancer (MBC) is an advanced stage of cancer, characterised by a highly nonlinear, heterogeneous process involving numerous singling pathways and ...
Sai Bhavani Gottumukkala +2 more
doaj +1 more source
Perturbation of EGF-induced MAP kinase activation by TGF-ß1
Brazilian Journal of Medical and Biological Research, 1999 TGF-ß1 regulates both cellular growth and phenotypic plasticity important for maintaining a growth advantage and increased invasiveness in progressively malignant cells.
C.E. Wenner, S. Yan
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Limit properties of induced mappings
Topology and its Applications, 2000 Given a mapping \(f:X\to Y\) between continua \(X\) and \(Y\), let \(2^f: 2^X\to 2^Y\) and \(C(f): C(X)\to C(Y)\) denote the corresponding induced mappings. Let \({\mathcal M}\) be a class of mappings between continua. A general problem which is related to a given mapping and to the two induced mappings is to find all interrelations between the ...
Charatonik, Janusz J. +1 more
openaire +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The transitivity of induced maps
Topology and its Applications, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Acosta, Gerardo +2 more
openaire +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
A Hofer-Type Norm of Hamiltonian Maps on Regular Poisson Manifold
Journal of Applied Mathematics, 2014 We define a Hofer-type norm for the Hamiltonian map on regular Poisson manifold and prove that it is nondegenerate. We show that the L1,∞-norm and the L∞-norm coincide for the Hamiltonian map on closed regular Poisson manifold and give some sufficient ...
Dawei Sun, Zhenxing Zhang
doaj +1 more source