Results 101 to 110 of about 390,247 (379)

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies [PDF]

, 2013
Human embryonic (hESC) and induced pluripotent (hiPSC) stem cells have broad therapeutic potential in the treatment of a range of diseases, including those of the vascular system.
Andrew H. Baker, Bonauer, Calatayud Maldonado, Caporali, Card, Case, Chambers, Chen, Chen, Cordes, Dews, Elizabeth Scott, Fang, Fang, Fasanaro, Feng, Fichtlscherer, Fong, Foshay, Fu, Geiszt, Gorski, Graeme Milligan, Grundmann, Guo, Harris, Hassel, Houbaviy, Howard, Hua, Humar, Iaconetti, Iorio, Jakob, Ji, Joanne Mountford, Kane, Kane, Kanellopoulou, Kazenwadel, Knight, Komal Loya, Kong, Kuehbacher, Lakshmipathy, Lange, Laurent, Lee, Lee, Lee, Lee, Lee, Li, Lin, Lou, Lou, Luczak, Lund, Magenta, Marson, McDonald, Mineno, Miyoshi, Murai, Murchison, O'Donnell, Ono, Otsubo, Poliseno, Qi, Rhee, Rosa, Rottiers, Sauer, Schmelter, Sessa, Shi, Shilo, Smith, Stadler, Suarez, Suarez, Suh, Sun, Takahashi, Taylor, Taylor, Thomson, Tojo, Treguer, Uno, Ushio-Fukai, Ushio-Fukai, van Grunsven, Wang, Wang, West, White, Wightman, Wigle, Wurdinger, Xu, Yu, Zhang, Zhang   +104 more
core   +1 more source

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.

Tissue Engineering. Part C, Methods, 2015
Contractile motion is the simplest metric of cardiomyocyte health in vitro, but unbiased quantification is challenging. We describe a rapid automated method, requiring only standard video microscopy, to analyze the contractility of human-induced ...
Nathaniel Huebsch, P. Loskill, P. Loskill, M. Mandegar, Natalie C Marks, Alice Sheehan, Zhen Ma, Anurag Mathur, Anurag Mathur, Trieu Nguyen, Jennie C Yoo, Luke M. Judge, C. I. Spencer, Anand C. Chukka, Caitlin R Russell, P. So, B. Conklin, K. Healy, K. Healy   +18 more
semanticscholar   +1 more source

Induced Pluripotent Stem Cells in Cardiovascular Medicine [PDF]

Stem Cells International, 2011
Induced pluripotent stem (iPS) cells are generated by reprogramming human somatic cells through the forced expression of several embryonic stem (ES) cell-specific transcription factors. The potential of iPS cells is having a significant impact on regenerative medicine, with the promise of infinite self-renewal, differentiation into multiple cell types,
Shinsuke Yuasa, Toru Egashira, Keiichi Fukuda   +2 more
openaire   +4 more sources

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Our Bodies, Our Cells: FDA Regulation of Autologous Adult Stem Cell Therapies [PDF]

, 2013
Stem cells have been an endless source of fascination and controversy since Dolly the sheep was cloned in 1996. This month’s announcement of a cloned human embryo from a single skin cell came on the heels of Sir John B. Gurdon and Dr.
Chirba, Mary Ann, Noble, Alice
core  

Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. [PDF]

, 2015
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits.
Biswas, Sangita, Deng, Wenbin, Qin, Xin, Xiao, Juan, Yang, Rongbing, Zhang, Min   +5 more
core   +3 more sources

Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs possible therapeutic agents, and an increasing number ...
Chengzhu Zhao, M. Ikeya
semanticscholar   +1 more source

Induced Pluripotent Stem Cells and Periodontal Regeneration [PDF]

Current Oral Health Reports, 2015
Periodontitis is a chronic inflammatory disease which leads to destruction of both the soft and hard tissues of the periodontium. Tissue engineering is a therapeutic approach in regenerative medicine that aims to induce new functional tissue regeneration via the synergistic combination of cells, biomaterials, and/or growth factors.
Xuejing Duan, Mi Du, Pishan Yang
openaire   +3 more sources

Pathway Analyses of Inherited Neuropathies Identify Putative Common Mechanisms of Axon Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Inherited neuropathies (IN) are associated with over 100 different genetic mutations presenting with a variety of phenotypes. This complexity suggests multiple pathways may converge onto a limited number of downstream pathways to effect axonal injury.
Christopher R. Cashman, Craig Blackstone, Reza Sadjadi   +2 more
wiley   +1 more source