Results 121 to 130 of about 310,335 (273)

Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons [PDF]

, 2009
Saravanan Karumbayaram, Bennett G. Novitch, Michaela Patterson, Joy A. Umbach, Laura Richter, Anne Lindgren, Anne E. Conway, Amander T. Clark, Steven A. Goldman, Kathrin Plath, Martina Wiedau‐Pazos, Harley I. Kornblum, William E. Lowry   +12 more
openalex   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells under Xeno-free Conditions [PDF]

, 2009
Ignasi Rodríguez-Pizà, Yvonne Richaud‐Patín, Rita Vassena, Federico González, María J. Barrero, Anna Veiga, Ángel Raya, Juan Carlos Izpisúa Belmonte   +7 more
openalex   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Cancer emergence is associated with a series of cellular transformations that include acquired drug resistance followed by tumor metastasis. Matrix metalloproteinases (MMPs) and Hsp90 chaperone are implicated in tumor progression, however, they are not studied in the context of drug resistance. Aims In the present study, we aimed at
Pankaj Kumar, Satish Siripini, Amere Subbarao Sreedhar   +2 more
wiley   +1 more source

Generation of an induced pluripotent stem cell line SYSUi-004-A from a child of microcephaly with TYW1 mutations

Stem Cell Research, 2020
We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents.
Chuanbo Sun, Pei Zhou, Simin Yuan, Ruirui Guo, Zhan Zhang, Qingyang Xu, Dingding Han, Lu He, Hongmei Tang, Kaishou Xu, Hao Hu, Na Li   +11 more
doaj  

Orderly hematopoietic development of induced pluripotent stem cells via Flk‐1⁺ hemoangiogenic progenitors [PDF]

, 2009
Akira Niwa, Katsutsugu Umeda, Hsi Chang, Megumu K. Saito, Keisuke Okita, Kazutoshi Takahashi, Masato Nakagawa, Shinya Yamanaka, Tatsutoshi Nakahata, Toshio Heike   +9 more
openalex   +1 more source

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration

Advanced Science, EarlyView.
A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou, Zhendong Lv, Zehao Chen, Yiming Xu, Chao Lin, Li Liu, Hao Chen, Bing Niu, Wenguo Cui, Yuhui Zhang   +9 more
wiley   +1 more source

Molecular and cellular paradigms of multidrug resistance in cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya, Abu Sufiyan Chhipa, Vinita Mishra, Vishal Kumar Gupta, Shiv Govind Rawat, Ajay Kumar, Chandramani Pathak   +6 more
wiley   +1 more source

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins [PDF]

, 2009
Hongyan Zhou, Shili Wu, Jin Young Joo, Saiyong Zhu, Dong‐Wook Han, Tongxiang Lin, Sunia A. Trauger, Geoffery Bien, Susan Yao, Yong Zhu, Gary Siuzdak, Hans R. Schöler, Lingxun Duan, Sheng Ding   +13 more
openalex   +1 more source