Results 141 to 150 of about 394,249 (378)

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology. [PDF]

, 2014
Our understanding of Alzheimer's disease (AD) is still incomplete and, as a result, we lack effective therapies. Reprogramming to generate human-induced pluripotent stem cells provides a new approach to the generation of human neurons that carry the ...
Goldstein, Lawrence SB, Reyna, Sol, Woodruff, Grace   +2 more
core   +1 more source

Generation of an induced pluripotent stem cell line from chorionic villi of a Patau syndrome spontaneous abortion

Stem Cell Research, 2020
Patau syndrome is a rare congenital malformation syndrome due to the presence of an extra chromosome 13. In this paper, we report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early ...
Ping Long, Zheng Liu, Bangyong Wu, Jingxi Chen, Chao Sun, Fei Wang, Yuanhua Huang, Hongjian Chen, Qi Li, Yanlin Ma   +9 more
doaj  

Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods

Scientific Reports, 2015
The renal proximal tubule is a main target for drug-induced toxicity. The prediction of proximal tubular toxicity during drug development remains difficult.
Karthikeyan Kandasamy, Jacqueline Kai Chin Chuah, R. Su, Peng Huang, Kim Guan Eng, Sijing Xiong, Yao Li, Chun Siang Chia, L. Loo, D. Zink   +9 more
semanticscholar   +1 more source

Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro

Advanced Healthcare Materials, EarlyView.
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski, Svenja Nellinger, Franziska Brigitte Albrecht, Petra Juliane Kluger   +3 more
wiley   +1 more source

Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]

, 2015
Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom, Marinho, Paulo A, Muotri, Alysson R   +2 more
core   +1 more source

Integration of Bioengineered Tools in Assisted Reproductive Technologies

Advanced Healthcare Materials, EarlyView.
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak, Edith Coonen, Ron van Golde, Erik Vrij   +3 more
wiley   +1 more source

Induced pluripotent stem cells and hepatic differentiation

Journal of the Chinese Medical Association, 2013
Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells to a pluripotent state by the introduction of specific factors. They can be generated from cells of different origins, such as fibroblasts, keratinocytes, hepatocytes, and blood.
Yueh Chien, Shou-Dong Lee, Cho Chin Sun, Jung Hung Hsieh, Chih Hung Chiang, Chih Hung Chiang, Kai Hsi Lu, Kai Hsi Lu, Teh Ia Huo, Teh Ia Huo   +9 more
openaire   +3 more sources

Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods

Cells
Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated
Kirstin O. McDonald, Nikita M. A. Lyons, Luca K. C. Gray, Janet B. Xu, Lucia Schoderboeck, Stephanie M. Hughes, Indranil Basak   +6 more
doaj   +1 more source

The Promise of Human Induced Pluripotent Stem Cells in Dental Research

Stem Cells International, 2012
Induced pluripotent stem cell-based therapy for treating genetic disorders has become an interesting field of research in recent years. However, there is a paucity of information regarding the applicability of induced pluripotent stem cells in dental ...
Thekkeparambil Chandrabose Srijaya, Padmaja Jayaprasad Pradeep, Rosnah Binti Zain, Sabri Musa, Noor Hayaty Abu Kasim, Vijayendran Govindasamy   +5 more
doaj   +1 more source