Results 151 to 160 of about 310,335 (273)
Alzheimer's &Dementia, EarlyView.Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz +11 more
wiley +1 more source
Efficient Adipocyte and Osteoblast Differentiation from Mouse Induced Pluripotent Stem Cells by Adenoviral Transduction [PDF]
, 2009 Katsuhisa Tashiro +6 more
openalex +1 more source
Research progress and application prospect of induced pluripotent stem cells
, 2008 Guoqiang Liu, Tianpei Hong
openalex +1 more source
Animal Models and Experimental Medicine, EarlyView.The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou +5 more
wiley +1 more source
Enhanced Generation of Induced Pluripotent Stem Cells from a Subpopulation of Human Fibroblasts
, 2009 James Byrne +2 more
openalex +2 more sources
A simple and efficient cryopreservation method for feeder-free dissociated human induced pluripotent stem cells and human embryonic stem cells [PDF]
, 2009 Sepideh Mollamohammadi +6 more
openalex +1 more source
Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
Integrated brain on a chip and automated organ‐on‐chips systems
Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023 Organ‐on‐chips (OOCs) related to brain functions have been used in drug development and disease simulation in vitro. However, modeling of complex biological systems remains a major challenge. In this paper, the compositions of the OOCs are optimized, and an automatic integrated system model is designed. It is expected to boost life science research and
Zhe Li +3 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai +7 more
wiley +1 more source