Results 181 to 190 of about 394,249 (378)

Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells

JACC: Basic to Translational Science, 2018
Summary: A novel myosin heavy chain 7 mutation (E848G) identified in a familial cardiomyopathy was studied in patient-specific induced pluripotent stem cell–derived cardiomyocytes.
Kai-Chun Yang, MD, Astrid Breitbart, MD, Willem J. De Lange, PhD, Peter Hofsteen, PhD, Akiko Futakuchi-Tsuchida, BS, Joy Xu, MSE, Cody Schopf, BS, Maria V. Razumova, PhD, Alex Jiao, PhD, Robert Boucek, MD, Lil Pabon, PhD, Hans Reinecke, PhD, Deok-Ho Kim, PhD, J. Carter Ralphe, MD, Michael Regnier, PhD, Charles E. Murry, MD, PhD   +15 more
doaj  

Multimodal Platforms for Light‐Mediated Organic Bioelectronics

Advanced Materials Interfaces, EarlyView.
Optobioelectronic devices are paving the way for different types of interfacing with cells, in addition to classical electrical interfacing. Here, a future perspective for research in this field is discussed, in which different classes of light‐responsive materials are combined to create a highly dynamic interface that truly integrates with biological ...
Giovanna Gentile, Mehdi Ravandeh, Luisa Petti, Francesca D'Elia, Francesca Santoro   +4 more
wiley   +1 more source

Bioengineered Models of Nerve Regeneration

Advanced Materials Technologies, EarlyView.
Bioengineered nerve regeneration platforms ranging from patterned cell cultures and hydrogels to fibrous scaffolds and microfluidic systems are reviewed, highlighting the complex cellular and biochemical environments essential for nerve repair. Challenges associated with these platforms, such as balancing complexity with throughput and the need for ...
Madalynn Jade Thompson, John Paul Frampton   +1 more
wiley   +1 more source

Induced Pluripotent Stem Cells in Cardiovascular Research

, 2012
The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSC) by overexpression of a combination of transcription factors bears the potential to spawn a wealth of new applications in both preclinical and clinical cardiovascular research.
Ralf J. Dirschinger, Alessandra Moretti, Alexander Goedel, Daniel Sinnecker, Peter Lipp, Karl-Ludwig Laugwitz   +5 more
openaire   +3 more sources

Induced pluripotent stem cell technology: a decade of progress

Nature reviews. Drug discovery, 2016
Yanhong Shi, H. Inoue, Joseph C. Wu, S. Yamanaka   +3 more
semanticscholar   +1 more source

Microfluidic Platform with Local Oxygen Sensors Demonstrates That 3D Blood Vessel Networks Exhibit Time‐Dependent Changes in Oxygen Concentrations During Their Formation and Perfusion

Advanced Materials Technologies, EarlyView.
Novel OoC platform with functional vascular networks highlights challenges in oxygenation. This study uses optical oxygen sensors to monitor oxygen during vascular formation, revealing perfusion limitations and highlighting the need for better oxygenation strategies.
Tarek Gensheimer, Stefanie Fuchs, Laura E. de Heus, Kim Vermeul, Torsten Mayr, Andries v.d. Meer   +5 more
wiley   +1 more source

Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease [PDF]

, 2009
Krishanu Saha, Rudolf Jaenisch
openalex   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Differentiation of definitive endoderm from human induced pluripotent stem cells on hMSCs feeder in a defined medium [PDF]

, 2016
Background: The Definitive Endoderm (DE) differentiation using the undefined media and non-human feeders can cause contaminations in the generated cells for therapeutic applications.
Geramizadeh, B., Hosseinkhani, S., Jaafarpour, Z., Karimi, M.H., Mobarra, N., Soleimani, M., Yaghmaei, P.   +6 more
core  

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins [PDF]

, 2009
Hongyan Zhou, Shili Wu, Jin Young Joo, Saiyong Zhu, Dong‐Wook Han, Tongxiang Lin, Sunia A. Trauger, Geoffery Bien, Susan Yao, Yong Zhu, Gary Siuzdak, Hans R. Schöler, Lingxun Duan, Sheng Ding   +13 more
openalex   +1 more source