Results 11 to 20 of about 406,426 (351)

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer [PDF]

Circulation, 2019
BACKGROUND Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their use and impair patients' quality of life.
Tomoya Kitani, Sang‐Ging Ong, Chi Keung Lam, June‐Wha Rhee, Joe Z. Zhang, Angelos Oikonomopoulos, Nan Ma, Lei Tian, Jaecheol Lee, Melinda L. Telli, Ronald Witteles, Arun Sharma, Nazish Sayed, Joseph C. Wu   +13 more
openalex   +2 more sources

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]

Stem Cells International, 2016
A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Aoife Gowran, Marco Rasponi, Roberta Visone, Patrizia Nigro, Gianluca L. Perrucci, Stefano Righetti, Marco Zanobini, Giulio Pompilio   +7 more
doaj   +9 more sources

Induced pluripotent stem cell–related approaches to generate dopaminergic neurons for Parkinson’s disease [PDF]

Neural Regeneration Research
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson’s disease, the second most common human neurodegenerative disease.
Ling-Xiao Yi, Hui Ren Woon, Genevieve Saw, Li Zeng, Eng King Tan, Zhi Dong Zhou   +5 more
doaj   +2 more sources

An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]

, 2017
Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan, Bowles, Kathryn R, Brennand, Kristen J, Goate, Alison M, Hartley, Brigham J, Karch, Celeste M, Lacin, Emre, Machlovi, Saima I, Phatnani, Hemali, Pimenova, Anna A, Slesinger, Paul A, TCW, Julia, Wang, Minghui, Zhang, Bin   +13 more
core   +18 more sources

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

Tissue Engineering. Part C, Methods, 2014
Nathaniel Huebsch, Peter Loskill, Mohammad A. Mandegar, Natalie C. Marks, Alice S. Sheehan, Zhen Ma, Anurag Mathur, Trieu N. Nguyen, Jennie Yoo, Luke M. Judge, C. Ian Spencer, Anand C. Chukka, Caitlin R. Russell, Po-Lin So, Bruce R. Conklin, Kevin E. Healy   +15 more
openalex   +2 more sources

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

Frontiers in Immunology, 2021
Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties.
Joel Jihwan Hwang, Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju, Ji Hyeon Ju   +4 more
doaj   +1 more source

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
We examined whether it is possible to directly detect citrullinated antigens in the serum of rheumatoid arthritis (RA) patients using a monoclonal antibody (mAb) designed to be specific for citrullinated peptides. In order to confirm the potential of the
Pureun Won, Pureun Won, Youngkyun Kim, Youngkyun Kim, Youngkyun Kim, Hyerin Jung, Hyerin Jung, Yeri Alice Rim, Yeri Alice Rim, Dong Hyun Sohn, Dong Hyun Sohn, Dong Hyun Sohn, William H. Robinson, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju   +17 more
doaj   +1 more source

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction

Scientific Reports, 2022
The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Göritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvák, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, Micha Drukker   +21 more
doaj   +1 more source

Cell reprogramming shapes the mitochondrial DNA landscape

Nature Communications, 2021
Here the authors describe high depth mitochondrial DNA (mtDNA) sequence analysis of 146 human induced pluripotent stem cell (hiPSC) lines as well as single cell RNA-seq (scRNAseq) of hiPSCs undergoing differentiation from 125 donors; reporting mtDNA ...
Wei Wei, Daniel J. Gaffney, Patrick F. Chinnery   +2 more
doaj   +1 more source

Supporting dataset of two integration-free induced pluripotent stem cell lines from related human donors

Data in Brief, 2021
Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripotent ...
Anja Patricia Ramme, Daniel Faust, Leopold Koenig, Nhutuyen Nguyen, Uwe Marx   +4 more
doaj   +1 more source