Results 11 to 20 of about 394,249 (378)

Epigenetic memory in induced pluripotent stem cells [PDF]

Nature, 2010
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, these two reprogramming methods reset genomic methylation, an epigenetic modification of DNA that influences gene expression ...
K. Kim, Akiko Doi, Bo Wen, Kelvin S. Ng, Robert Chunhua Zhao, Patrick Cahan, Jonghwan Kim, Martin J. Aryee, Hong Ji, Lauren I. R. Ehrlich, Akiko Yabuuchi, Ayumu Takeuchi, K. C. Cunniff, Hongguang Huo, Shannon McKinney‐Freeman, Olaia Naveiras, Taeyeong Yoon, Rafael A. Irizarry, Namyoung Jung, Jun Seita, Jacob H. Hanna, Peter Murakami, Rudolf Jaenisch, Ralph Weissleder, Stuart H. Orkin, Irving L. Weissman, Andrew P. Feinberg, George Q. Daley   +27 more
core   +11 more sources

Induced pluripotent stem cell–related approaches to generate dopaminergic neurons for Parkinson’s disease [PDF]

Neural Regeneration Research
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson’s disease, the second most common human neurodegenerative disease.
Ling-Xiao Yi, Hui Ren Woon, Genevieve Saw, Li Zeng, Eng King Tan, Zhi Dong Zhou   +5 more
doaj   +2 more sources

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]

Stem Cells International, 2016
A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Aoife Gowran, Marco Rasponi, Roberta Visone, Patrizia Nigro, Gianluca L. Perrucci, Stefano Righetti, Marco Zanobini, Giulio Pompilio   +7 more
doaj   +8 more sources

Induced Pluripotent Stem Cells and Human Disease [PDF]

Cell Stem Cell, 2008
Two recent studies report the generation of induced pluripotent stem cells from patients presenting with a total of eleven different diseases (Park et al., 2008; Dimos et al., 2008). Future differentiation studies using these lines may offer insight on specific disease pathophysiology and aid the design of protective drug therapies.
Alan Colman
openalex   +5 more sources

An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]

, 2017
Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan, Bowles, Kathryn R, Brennand, Kristen J, Goate, Alison M, Hartley, Brigham J, Karch, Celeste M, Lacin, Emre, Machlovi, Saima I, Phatnani, Hemali, Pimenova, Anna A, Slesinger, Paul A, TCW, Julia, Wang, Minghui, Zhang, Bin   +13 more
core   +10 more sources

Pluripotency of induced pluripotent stem cells [PDF]

Journal of Animal Science and Biotechnology, 2012
Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Shaorong Gao, Lan Kang
openaire   +4 more sources

Induced pluripotent stem cells are induced pluripotent stem cell-like cells [PDF]

The Journal of Biomedical Research, 2015
Gold is rare and precious, while pyrite (FeS2) is abundant and cheap. Pyrite is nicknamed fool's gold, since pyrite looks like gold and it is even shinier and brighter than gold. It is very difficult to recognize the differences between a real natural gold and a gold-like rock (pyrite) to non-professional persons[1], but we know that all that glitters ...
Emanuel Goldman, Liting Song
openaire   +3 more sources

Induced Pluripotent Stem Cells and Hormesis [PDF]

Dose-Response, 2022
This paper represents the first assessment of agent-induced hormetic dose responses in induced pluripotent stem cells and their derived cells. The hormetic dose responses were induced by a broad range of chemicals, including pharmaceuticals (eg, metformin), dietary supplements/extracts from medicinal plants (eg, curcumin), and endogenous agents (eg ...
openaire   +3 more sources

Chromatin structure of pluripotent stem cells and induced pluripotent stem cells [PDF]

Briefings in Functional Genomics, 2011
Pluripotent embryonic stem (ES) cells are specialized cells with a dynamic chromatin structure, which is intimately connected with their pluripotency and physiology. In recent years somatic cells have been reprogrammed to a pluripotent state through over-expression of a defined set of transcription factors.
Paul Delgado-Olguin, Félix Recillas-Targa   +1 more
openaire   +3 more sources

Immunogenicity of Induced Pluripotent Stem Cells [PDF]

Circulation Research, 2011
### Immunogenicity of Induced Pluripotent Stem Cells Zhao et al Nature . 2011. doi:10.1038/nature10135 A new study shows the immunogenicity of induced pluripotent stem cells by the direct transplantation of undifferentiated cells into syngenic mice.
Shinya Yamanaka, Keisuke Okita, Naoki Nagata   +2 more
openaire   +6 more sources