Results 201 to 210 of about 390,247 (379)

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

Advanced Science, EarlyView.
This research presents a novel strategy employing the VGM cocktail, which combines HES7 overexpression with HDAC inhibitor and GABA, to enhance platelet production from hematopoietic stem and progenitor cells by promoting megakaryocyte progenitor (MkP) generation.
Huicong Liu, Lingna Wang, Jiaqing Liu, Haitao Yuan, Kaiqing Zhang, Yun Qiu, Fangfang Zhu   +6 more
wiley   +1 more source

Reprogrammed induced pluripotent stem cells: how suitable could they be in reproductive medicine? [PDF]

, 2009
Roberto Enseñat‐Waser, António Pellicer, Carlos Simón   +2 more
openalex   +1 more source

Resolving Artifacts in Voltage‐Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings

Advanced Science, EarlyView.
Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei, Alexander P. Clark, Michael Clerx, Siyu Wei, Meye Bloothooft, Teun P. de Boer, David J. Christini, Trine Krogh‐Madsen, Gary R. Mirams   +8 more
wiley   +1 more source

Suspended Tissue Open Microfluidic Patterning (STOMP)

Advanced Science, EarlyView.
Suspended Tissue Open Microfluidic Patterning (STOMP) is a method that enables precise spatial patterning within a single suspended tissue. By leveraging capillary pinning and open microfluidics, STOMP facilitates the creation of complex tissue interfaces such as diseased‐healthy boundaries and tissue‐tissue junctions. This method integrates mechanical
Amanda J. Haack, Lauren G. Brown, Alex J. Goldstein, Priti Mulimani, Jean Berthier, Asha R. Viswanathan, Irina Kopyeva, Jamison M. Whitten, Ariel Lin, Serena H. Nguyen, Thomas P. Leahy, Ella E. Bouker, Ruby M. Padgett, Natalie A. Mazzawi, Jodie C. Tokihiro, Ross C. Bretherton, Aaliyah Wu, Stephen J. Tapscott, Cole A. DeForest, Tracy E. Popowics, Erwin Berthier, Nathan J. Sniadecki, Ashleigh B. Theberge   +22 more
wiley   +1 more source

Generation of functional human hepatic endoderm from human induced pluripotent stem cells [PDF]

, 2009
Gareth J. Sullivan, David C. Hay, In-Hyun Park, Judy Fletcher, Zara Hannoun, Catherine Payne, Donna Dalgetty, James R. Black, James A. Ross, Kay Samuel, Gang Wang, George Q. Daley, Je-Hyuk Lee, George M. Church, Stuart J. Forbes, John P. Iredale, Ian Wilmut   +16 more
openalex   +1 more source

Neurológiai és pszichiátriai betegségek in vitro modellezése indukált pluripotens őssejtek felhasználásával: fókuszban az Alzheimer-kór és a szkizofrénia [PDF]

, 2017
Over the past decade we witnessed the birth of a new scientific area that lies at the borders of developmental biology, stem cell biology, basic and clinical neuroscience.
Apáti Ágota, Hathy, Edit, Kálmán, Sára, Nemoda, Zsófia, Réthelyi, János   +4 more
core  

Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue

Circulation, 2016
Jia‐Ling Ruan, Nathaniel L. Tulloch, M. Razumova, Mark Saiget, V. Muskheli, Lil Pabon, H. Reinecke, Michael Regnier, C. Murry   +8 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors

, 2008
Wenlin Li, Wei Wei, Saiyong Zhu, Jinliang Zhu, Yan Shi, Tongxiang Lin, Ergeng Hao, Alberto Hayek, Hongkui Deng, Sheng Ding   +9 more
openalex   +1 more source

Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

Toxicological Sciences, 2017
K. Blinova, J. Stohlman, J. Vicente, Dulciana D. Chan, L. Johannesen, M. P. Hortigon-Vinagre, V. Zamora, Godfrey L. Smith, W. Crumb, Li Pang, B. Lyn-Cook, James D. Ross, Mathew Brock, Stacie A. Chvatal, Daniel C Millard, L. Galeotti, N. Stockbridge, D. Strauss   +17 more
semanticscholar   +1 more source