Results 211 to 220 of about 210,167 (295)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Induced Pluripotent Stem Cell-Derived Dendritic Cells Provide a Reliable In Vitro Platform for Functional Screening of Immunoregulatory Probiotics. [PDF]

Int J Mol Sci
Chiang YL, Chiew MY, Lim SJ, Chou DL, Lu HE, Tseng CP.   +5 more
europepmc   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Heterogeneity and optimal study design between cell lines in induced pluripotent stem cell-based cardiac disease modeling. [PDF]

Stem Cells Transl Med
Maas RGC, Denning C, Sluijter JPG.
europepmc   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Development of a novel in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes. [PDF]

Genes Environ
Kobayashi R, Sasaki K, Matsuyama R, Saito K, Kumagai A, Kitayama S, Kawai Y, Kaneko S.   +7 more
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells. [PDF]

Stem Cell Res Ther
Aoki T, Kobayashi M, Okoshi M, Yamaguchi M, Okura H, Sasaki S, Sasako Y, Kira S, Chang YH, Yakushiji-Kaminatsui N, Sharif J, Matsuda M, Kiuchi M, Hirahara K, Kimura MY, Motohashi S, Koseki H.   +16 more
europepmc   +1 more source

Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

Droplet, EarlyView.
Droplet microfluidics enables precise, versatile fabrication of hydrogel particles with controlled size, composition, and structure. This review summarizes fundamental principles, engineering strategies, and emerging applications, providing a framework for advancing microfluidic hydrogel technologies.
Zhongqiao Gan, Xu Hou
wiley   +1 more source

Human induced pluripotent stem cell-derived inner ear organoids reveal hair cell damage and plasticity after cisplatin and gentamicin exposure. [PDF]

Dis Model Mech
Lucassen AWA, van den Boogaard WMC, Fousert E, Zhang J, Koehler KR, de Groot JCMJ, van Benthem PPG, van der Valk WH, Locher H.   +8 more
europepmc   +1 more source