Results 251 to 260 of about 310,335 (273)

MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez, Thomas Lilieholm, Walter F. Block   +2 more
wiley   +1 more source

Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cell-Based Models. [PDF]

Life (Basel)
Wang BX.
europepmc   +1 more source

Pain Assessment in Osteoarthritis: Present Practices and Future Prospects Including the Use of Biomarkers and Wearable Technologies, and AI‐Driven Personalized Medicine

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Osteoarthritis (OA) is a highly prevalent chronic joint disorder affecting ~600 million individuals worldwide and is characterized by complex pain mechanisms that significantly impair patient quality of life. Challenges exist in accurately assessing and measuring pain in OA due to variations in pain perception among individuals and the ...
Shujaa T. Khan, Nick Huffman, Xiaojuan Li, Anukriti Sharma, Carl S. Winalski, Eric T. Ricchetti, Kathleen Derwin, Suneel S. Apte, Daniel Rotroff, Carl Y. Saab, Nicolas S. Piuzzi   +10 more
wiley   +1 more source

Generation of Advanced Blood-Brain Barrier Spheroids Using Human-Induced Pluripotent Stem Cell-Derived Brain Capillary Endothelial-Like Cells. [PDF]

Adv Biol (Weinh)
Mathew-Schmitt S, Oerter S, Reitenbach E, Gätzner S, Höchner A, Jahnke HG, Piontek J, Neuhaus W, Brachner A, Metzger M, Appelt-Menzel A.   +10 more
europepmc   +1 more source

Cell‐based therapies have disease‐modifying effects on osteoarthritis in animal models: A systematic review by the ESSKA Orthobiologic Initiative. Part 3: Umbilical cord, placenta, and other sources for cell‐based injectable therapies

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This systematic review aimed to investigate in animal models the presence of disease‐modifying effects driven by non‐bone marrow‐derived and non‐adipose‐derived products, with a particular focus on umbilical cord and placenta‐derived cell‐based therapies for the intra‐articular injective treatment of osteoarthritis (OA).
Yosef Sourugeon, Angelo Boffa, Carlotta Perucca Orfei, Laura de Girolamo, Jeremy Magalon, Mikel Sánchez, Thomas Tischer, Giuseppe Filardo, Lior Laver   +8 more
wiley   +1 more source

Generation of human induced pluripotent stem cell lines derived from patients of cystic biliary atresia. [PDF]

Hum Cell
Ge N, Suzuki K, Sato I, Noguchi M, Nakamura Y, Matsuo-Takasaki M, Fujishiro J, Hayashi Y.   +7 more
europepmc   +1 more source

Bioelectronic Hydrogels: Exemplifying the Synergy Between Biopolymers and Conjugated Polymers

Macromolecular Materials and Engineering, EarlyView.
This review aims to highlight the benefits of biopolymer‐based conductive hydrogels as soft bioelectronics for biointerface applications. Biopolymers deliver biocompatibility, commercial availability, low cost, and sustainability, whereas conjugated polymers provide electronic conductivity.
Thanh Nhi Tra, Kristina Fidanovski, Damia Mawad   +2 more
wiley   +1 more source

Glutamine metabolism is systemically different between primary and induced pluripotent stem cell-derived brain microvascular endothelial cells. [PDF]

J Cereb Blood Flow Metab
Weber CM, Moiz B, Kheradmand M, Scott A, Kettula C, Wunderler B, Alpízar Vargas V, Clyne AM.   +7 more
europepmc   +1 more source

Electrospun Smart Hybrid Nanofibers for Multifaceted Applications

Macromolecular Rapid Communications, EarlyView.
The review provides a comprehensive overview of the applications of smart electrospun hybrid nanofibers in the fields of energy, catalysis, and biomedicine, highlighting their remarkable properties for diverse applications. Exploration of the challenges and recent progress in the development of smart hybrid nanofibers is conducted.
Viraj P. Nirwan, Altangerel Amarjargal, Rebecca Hengsbach, Amir Fahmi   +3 more
wiley   +1 more source