Results 261 to 270 of about 110,620 (281)

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of silk fibroin‐based biomaterials in spinal cord injury repair, focusing on environmentally friendly processing techniques, and the strategies for designing composite scaffolds as well as discussing the advantages and current challenges of silk fibroin‐based biomaterials in spinal ...
Xiaoliang Cui, Xuanwen Wang, Siying Liu, Lilei Wang, Menghong Li, Jun Zhang, Li Wang, Ke‐Qin Zhang   +7 more
wiley   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

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Induced Pluripotent Stem Cells

JAMA, 2015
Induced pluripotent stem cells (iPSCs) are the newest member of a growing list of stem cell populations that hold great potential for use in cell-based treatment approaches in the dental field. This review summarizes the dental tissues that have successfully been utilized to generate iPSC lines, as well as the potential uses of iPSCs for tissue ...
Kitchener D. Wilson, Kitchener D. Wilson, Joseph C. Wu, Joseph C. Wu   +3 more
openaire   +6 more sources

Induced Pluripotent Stem Cells

2010
Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an
Holm Zaehres, Hans R. Schöler, Jeong Beom Kim, Jeong Beom Kim   +3 more
openaire   +5 more sources

Induced pluripotent stem cells

Russian Journal of Genetics, 2009
Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC).
Sergey P. Medvedev, Suren M. Zakian, N. A. Mazurok, Alexander I. Shevchenko   +3 more
openaire   +2 more sources

Stem Cells, Induced Pluripotent

2021
Induced pluripotent stem cells (iPSCs) refer to a type of stem cell directly generated using reprogramming techniques from multipotent adult stem cells. Therefore iPSCs gained a lower level of differentiation and could present themselves as pluripotent.
Maria do Céu Patrão Neves, Henk ten Have   +1 more
openaire   +2 more sources

Induced Pluripotent Stem Cells [PDF]

, 2020
Progress in understanding and treatment of numerous human diseases has been hampered by the lack of representative human in vitro models, especially for diseases in which the affected cell types are difficult to obtain, such as heart diseases. Over the past decade, the use of disease affected cell types derived from induced pluripotent stem (iPS) cells
Pieter A. Doevendans, Geerthe Margriet Balk, Alain van Mil, Joost P.G. Sluijter, Jan W. Buikema, Klaus Neef   +5 more
openaire   +1 more source

Routes to induced pluripotent stem cells

Current Opinion in Genetics & Development, 2014
The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of hundreds of genes, making unique ...
Tyson Ruetz, Keisuke Kaji
openaire   +2 more sources