Results 31 to 40 of about 390,247 (379)
Circulation, 2019 BACKGROUND Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their use and impair patients' quality of life.
Tomoya Kitani +13 more
semanticscholar +1 more source
Haematologica, 2015 Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn +16 more
doaj +1 more source
Induced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency [PDF]
Cell Journal, 2020 Severe combined immunodeficiency (SCID) is classified as a primary immunodeficiency, which is characterized by impaired T-lymphocytes differentiation. IL2RG, IL7Ralpha, JAK3, ADA, RAG1/RAG2, and DCLE1C (Artemis) are the most defective genes in SCID.
Reza Kouchaki +6 more
doaj +1 more source
Quality control guidelines for clinical-grade human induced pluripotent stem cell lines.
Regenerative medicine, 2018 Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material for the generation of cellular therapeutics requires demonstration of comparability of lines derived from different individuals and in different facilities ...
S. Sullivan +28 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2018 Induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) serve as a unique source for cell therapy. We investigated whether exosomes from iMSCs promote the proliferation of human keratinocytes (HaCaT) and human dermal fibroblasts (HDFs)
Soo Kim +3 more
semanticscholar +1 more source
Stem cell research & therapeutics, 2017 BackgroundOsteoarthritis (OA) is the most common joint disease worldwide. In the past decade, mesenchymal stem cells (MSCs) have been used widely for the treatment of OA.
Yu Zhu +9 more
semanticscholar +1 more source
Cryopreservation of Induced Pluripotent Stem Cells [PDF]
Cell Medicine, 2012 Induced pluripotent stem (iPS) cells have attracted attention as a promising cell source for medical treatment that could replace marrow stromal cells (MSCs) and adipose tissue-derived stem cells (ASCs). These pluripotent cells can be induced in vitro and in vivo to differentiate into various tissues and organs.
Hisashi Iwata +6 more
openaire +3 more sources
World Journal of Stem Cells, 2021 Mesenchymal stem cells (MSCs) have received significant attention in recent years due to their large potential for cell therapy. Indeed, they secrete a wide variety of immunomodulatory factors of interest for the treatment of immune-related disorders and inflammatory diseases. MSCs can be extracted from multiple tissues of the human body.
Dupuis, Victoria +1 more
openaire +5 more sources
Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy. [PDF]
PLoS ONE, 2014 Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies indicate that ...
Andrew J Schwab, Allison D Ebert
doaj +1 more source
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
core +2 more sources