Results 31 to 40 of about 223,235 (338)

Embryos and embryonic stem cells from the white rhinoceros

Nature Communications, 2018
The Southern (SWR) and Northern (NWR) are two subspecies of the White Rhinoceros with the NWR being almost extinct. Here, using assisted reproduction technology, the authors produce and cryopreserve SWR purebred and NWR-SWR hybrid embryos developed to ...
Thomas B. Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn B. Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Göritz, Giovanna Lazzari, Cesare Galli   +12 more
doaj   +1 more source

Two sides of the same coin? Unraveling subtle differences between human embryonic and induced pluripotent stem cells by Raman spectroscopy

Stem Cell Research & Therapy, 2017
Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta, Maria Teresa De Angelis, Stefania Scalise, Patrizio Candeloro, Gianluca Santamaria, Mariagrazia Paonessa, Maria Laura Coluccio, Gerardo Perozziello, Stefania De Vitis, Antonella Sgura, Elisa Coluzzi, Vincenzo Mollace, Enzo Mario Di Fabrizio, Giovanni Cuda   +13 more
doaj   +1 more source

A novel -mutated human induced pluripotent stem cell model for understanding -mutated tumors

Tumor Biology, 2020
A missense mutation of the guanine nucleotide binding protein alpha stimulating activity polypeptide 1 ( GNAS ) gene, typically Arg201Cys or Arg201His (R201H/R201C), leads to constitutive activation of the Gsα-cyclic AMP (cAMP) signaling pathway that ...
Katsuhito Watanabe, Takashi Nakamura, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma   +5 more
doaj   +1 more source

Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]

PLoS ONE, 2014
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga   +13 more
doaj   +1 more source

Induced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency [PDF]

Cell Journal, 2020
Severe combined immunodeficiency (SCID) is classified as a primary immunodeficiency, which is characterized by impaired T-lymphocytes differentiation. IL2RG, IL7Ralpha, JAK3, ADA, RAG1/RAG2, and DCLE1C (Artemis) are the most defective genes in SCID.
Reza Kouchaki, Bahareh Abd-Nikfarjam, Amirhosein Maali, Saeid Abroun, Farshad Foroughi, Sasan Ghaffari, Mehdi Azad   +6 more
doaj   +1 more source

Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. [PDF]

, 2013
Cells are fundamental units of life, but little is known about evolution of cell states. Induced pluripotent stem cells (iPSCs) are once differentiated cells that have been re-programmed to an embryonic stem cell-like state, providing a powerful platform
Chen, CC, Dai, R, Hochgeschwender, U, Howard, JT, Jarvis, ED, Rosselló, RA   +5 more
core   +2 more sources

Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem [PDF]

, 2009
A central unanswered question in stem cell biology, both in plants and in animals, is how the spatial organization of stem cell niches are maintained as cells move through them.
Anders, Birnbaum, Brand, C. Ohno, Clark, Clark, Clark, Clark, E. M. Meyerowitz, Fletcher, Fletcher, Gallois, Gallois, Geier, Gordon, Haecker, Jasinski, Jonsson, Kayes, Kurakawa, Laux, Leibfried, Long, Mahonen, Mayer, Muller, Muller, S. P. Gordon, Sablowski, Schoof, Skoog, Tucker, V. S. Chickarmane, Yanai   +33 more
core   +2 more sources

Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy. [PDF]

PLoS ONE, 2014
Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies indicate that ...
Andrew J Schwab, Allison D Ebert
doaj   +1 more source

Induced Pluripotent Stem Cells

Cell Transplantation, 2018
Many neurodegenerative diseases are progressive, complex diseases without clear mechanisms or effective treatments. To study the mechanisms underlying these diseases and to develop treatment strategies, a reliable in vitro modeling system is critical. Induced pluripotent stem cells (iPSCs) have the ability to self-renew and possess the differentiation ...
Chia-Yu Chang, Hsiao-Chien Ting, Ching-Ann Liu, Hong-Lin Su, Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin   +6 more
openaire   +4 more sources

GMP-compatible and xeno-free cultivation of mesenchymal progenitors derived from human-induced pluripotent stem cells

Stem Cell Research & Therapy, 2019
Background Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity.
Madison McGrath, Edmund Tam, Martina Sladkova, Athbah AlManaie, Matthew Zimmer, Giuseppe Maria de Peppo   +5 more
doaj   +1 more source