Results 31 to 40 of about 406,426 (351)

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

Stem cell research & therapeutics, 2017
BackgroundOsteoarthritis (OA) is the most common joint disease worldwide. In the past decade, mesenchymal stem cells (MSCs) have been used widely for the treatment of OA.
Yu Zhu, Yuchen Wang, Bizeng Zhao, X. Niu, Bin Hu, Qing Li, Juntao Zhang, Jian Ding, Yunfeng Chen, Yang Wang   +9 more
semanticscholar   +1 more source

Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin

Haematologica, 2015
Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn, Katharina Klich, Marcos J. Arauzo-Bravo, Martina Radstaak, Simeon Santourlidis, Foued Ghanjati, Teja F. Radke, Olympia E. Psathaki, Gunnar Hargus, Jan Kramer, Martin Einhaus, Jeong Beom Kim, Gesine Kögler, Peter Wernet, Hans R. Schöler, Peter Schlenke, Holm Zaehres   +16 more
doaj   +1 more source

Improving single-cell cloning workflow for gene editing in human pluripotent stem cells [PDF]

, 2018
The availability of human pluripotent stem cells (hPSCs) and progress in genome engineering technology have altered the way we approach scientific research and drug development screens.
Chen, Yi-Hsien, Pruett-Miller, Shondra M
core   +2 more sources

Quality control guidelines for clinical-grade human induced pluripotent stem cell lines.

Regenerative medicine, 2018
Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material for the generation of cellular therapeutics requires demonstration of comparability of lines derived from different individuals and in different facilities ...
S. Sullivan, G. Stacey, C. Akazawa, N. Aoyama, R. Baptista, P. Bedford, Annelise Bennaceur Griscelli, A. Chandra, N. Elwood, M. Girard, S. Kawamata, Tadaaki Hanatani, T. Latsis, Stephen Lin, T. Ludwig, T. Malygina, Amanda A Mack, J. Mountford, S. Noggle, L. Pereira, Jack Price, M. Sheldon, A. Srivastava, H. Stachelscheid, S. Velayudhan, N. Ward, M. Turner, J. Barry, Jihwan Song   +28 more
semanticscholar   +1 more source

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Accelerate Skin Cell Proliferation

International Journal of Molecular Sciences, 2018
Induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) serve as a unique source for cell therapy. We investigated whether exosomes from iMSCs promote the proliferation of human keratinocytes (HaCaT) and human dermal fibroblasts (HDFs)
Soo Kim, S. Lee, Hyun-Jong Kim, Tae Min Kim   +3 more
semanticscholar   +1 more source

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA [PDF]

, 2016
Neurons differentiated from pluripotent stem cells using established neural culture conditions often exhibit functional deficits. Recently, we have developed enhanced media which both synchronize the neurogenesis of pluripotent stem cell-derived neural ...
Allen, Nicholas Denby, Badder, Luned, Brown, Jonathan T., Cope, Emma Louise, Geater, Charlene, Hancock, Jane M., Hughes, Alis, Kemp, Paul J, Randall, Andrew, Riccardi, Daniela, Rushton, David J., Schnell, Christian, Telezhkin, Vsevolod, Wieland, Annalena, Yarova, Polina   +14 more
core   +1 more source

Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]

PLoS ONE, 2014
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga   +13 more
doaj   +1 more source

Embryos and embryonic stem cells from the white rhinoceros

Nature Communications, 2018
The Southern (SWR) and Northern (NWR) are two subspecies of the White Rhinoceros with the NWR being almost extinct. Here, using assisted reproduction technology, the authors produce and cryopreserve SWR purebred and NWR-SWR hybrid embryos developed to ...
Thomas B. Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn B. Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Göritz, Giovanna Lazzari, Cesare Galli   +12 more
doaj   +1 more source

Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem [PDF]

, 2009
A central unanswered question in stem cell biology, both in plants and in animals, is how the spatial organization of stem cell niches are maintained as cells move through them.
Anders, Birnbaum, Brand, C. Ohno, Clark, Clark, Clark, Clark, E. M. Meyerowitz, Fletcher, Fletcher, Gallois, Gallois, Geier, Gordon, Haecker, Jasinski, Jonsson, Kayes, Kurakawa, Laux, Leibfried, Long, Mahonen, Mayer, Muller, Muller, S. P. Gordon, Sablowski, Schoof, Skoog, Tucker, V. S. Chickarmane, Yanai   +33 more
core   +2 more sources