Results 51 to 60 of about 390,247 (379)

A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources

Journal of Physiology, 2019
Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of cardiac electrical activity Computational modelling and simulation provide a high throughput
Divya C. Kernik, S. Morotti, Haodi Wu, Priyanka Garg, H. Duff, J. Kurokawa, J. Jalife, Joseph C. Wu, E. Grandi, C. Clancy   +9 more
semanticscholar   +1 more source

Editorial: Reviews in induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2023
No abstract ...
Mirella Dottori, Wan-Ju Li, Gabriella Minchiotti, Alessandro Rosa, Alessandro Rosa, Federica Sangiuolo   +5 more
openaire   +6 more sources

Supporting dataset of two integration-free induced pluripotent stem cell lines from related human donors

Data in Brief, 2021
Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripotent ...
Anja Patricia Ramme, Daniel Faust, Leopold Koenig, Nhutuyen Nguyen, Uwe Marx   +4 more
doaj  

Regenerative strategies for kidney engineering [PDF]

, 2016
The kidney is the most important organ for water homeostasis and waste excretion. It performs several important physiological functions for homeostasis: it filters the metabolic waste out of circulation, regulates body fluid balances, and acts as an ...
Garreta, Elena, Izpisúa Belmonte, Juan Carlos, Montserrat, Núria   +2 more
core   +1 more source

Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association.

Circulation Research, 2019
It is now well recognized that many lifesaving oncology drugs may adversely affect the heart and cardiovascular system, including causing irreversible cardiac injury that can result in reduced quality of life.
G. Gintant, P. Burridge, L. Gepstein, S. Harding, T. Herron, C. Hong, J. Jalife, Joseph C. Wu   +7 more
semanticscholar   +1 more source

GMP-compatible and xeno-free cultivation of mesenchymal progenitors derived from human-induced pluripotent stem cells

Stem Cell Research & Therapy, 2019
Background Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity.
Madison McGrath, Edmund Tam, Martina Sladkova, Athbah AlManaie, Matthew Zimmer, Giuseppe Maria de Peppo   +5 more
doaj   +1 more source

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. [PDF]

, 2017
A major challenge in stem cell differentiation is the availability of bioassays to prove cell types generated in vitro are equivalent to cells in vivo. In the mouse, differentiation of primordial germ cell-like cells (PGCLCs) from pluripotent cells was ...
Chen, Di, Clark, Amander T, Hennebold, Jon D, Lam, Truong N, Meistrich, Marvin L, Mitchell, Jennifer M, Orwig, Kyle E, Peters, Karen A, Rojas, Ernesto J, Shetty, Gunapala, Sosa, Enrique, Sukhwani, Meena, Tailor, Ramesh C, Wu, Zhuang   +13 more
core   +2 more sources

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA [PDF]

, 2016
Neurons differentiated from pluripotent stem cells using established neural culture conditions often exhibit functional deficits. Recently, we have developed enhanced media which both synchronize the neurogenesis of pluripotent stem cell-derived neural ...
Allen, Nicholas Denby, Badder, Luned, Brown, Jonathan T., Cope, Emma Louise, Geater, Charlene, Hancock, Jane M., Hughes, Alis, Kemp, Paul J, Randall, Andrew, Riccardi, Daniela, Rushton, David J., Schnell, Christian, Telezhkin, Vsevolod, Wieland, Annalena, Yarova, Polina   +14 more
core   +1 more source

A pathologist's perspective on induced pluripotent stem cells [PDF]

Laboratory Investigation, 2017
Induced pluripotent stem cell (iPSC) technology was originally developed in 2006. Essentially, it converts somatic cells into pluripotent stem cells by transiently expressing a few transcriptional factors. Once generated, these iPSCs can differentiate into all the cell types of our body, theoretically, which has attracted great attention for clinical ...
Noriko Watanabe, Anthony T. Yachnis, Naohiro Terada, Katherine E. Santostefano   +3 more
openaire   +3 more sources

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

Haematologica, 2012
Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells ...
Ladan Kobari, Frank Yates, Noufissa Oudrhiri, Alain Francina, Laurent Kiger, Christelle Mazurier, Shaghayegh Rouzbeh, Wassim El-Nemer, Nicolas Hebert, Marie-Catherine Giarratana, Sabine François, Alain Chapel, Hélène Lapillonne, Dominique Luton, Annelise Bennaceur-Griscelli, Luc Douay   +15 more
doaj   +1 more source