Results 61 to 70 of about 390,247 (379)

Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity

SAGE Open Medicine, 2020
Objectives: To establish a straightforward single-cell passaging cultivation method that enables high-quality maintenance of human induced pluripotent stem cells without the appearance of karyotypic abnormalities or loss of pluripotency.
Estela Cruvinel, Isabella Ogusuku, Rosanna Cerioni, Sirlene Rodrigues, Jéssica Gonçalves, Maria Elisa Góes, Juliana Morais Alvim, Anderson Carlos Silva, Vanesca de Souza Lino, Enrique Boccardo, Ernesto Goulart, Alexandre Pereira, Rafael Dariolli, Marcos Valadares, Diogo Biagi   +14 more
doaj   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Biomaterial-Free Three-Dimensional Bioprinting of Cardiac Tissue using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

Scientific Reports, 2017
We have developed a novel method to deliver stem cells using 3D bioprinted cardiac patches, free of biomaterials. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC) were aggregated to ...
C. Ong, T. Fukunishi, Huaitao Zhang, C. Huang, Andrew Nashed, A. Blazeski, D. Disilvestre, L. Vricella, J. Conte, L. Tung, G. Tomaselli, N. Hibino   +11 more
semanticscholar   +1 more source

Induced pluripotent stem cells in infections [PDF]

International Journal of Blood Transfusion and Immunohematology, 2015
Regenerative medicine has an exciting role in the treatment of disorders and conditions where there is an irreversible damage to a tissue or an organ or in immunodeficient state. Stem cells which have the potential to differentiate into specific types of cells, offers a new concept of regenerative medicine to treat spectrum of diseases including ...
Usha Bhoria, Anubha Singh, Deepak Kumar Singh   +2 more
openaire   +1 more source

Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

Haematologica, 2010
Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne, Ladan Kobari, Christelle Mazurier, Philippe Tropel, Marie-Catherine Giarratana, Isabelle Zanella-Cleon, Laurent Kiger, Marie Wattenhofer-Donzé, Hélène Puccio, Nicolas Hebert, Alain Francina, Georges Andreu, Stéphane Viville, Luc Douay   +13 more
doaj   +1 more source

Advances in human stem cell therapies: pre-clinical studies and the outlook for central nervous system regeneration

Neural Regeneration Research, 2021
Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical settings. There are several types of stem cells currently being used for pre-clinical regenerative
Lindsey H Forbes, Melissa R Andrews
doaj   +1 more source

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

Nature Biomedical Engineering, 2017
An in vitro model of the human kidney glomerulus—the major site of blood filtration—could facilitate drug discovery and illuminate kidney-disease mechanisms.
Samira Musah, A. Mammoto, Thomas C. Ferrante, Sauveur S. F. Jeanty, Mariko Hirano-Kobayashi, T. Mammoto, K. Roberts, Seyoon Chung, R. Novák, Miles Ingram, Tohid Fatanat-Didar, Sandeep T. Koshy, J. Weaver, G. Church, D. Ingber   +14 more
semanticscholar   +1 more source

Efficacy of MUC1-targeted CAR-NK cells against human tongue squamous cell carcinoma

Frontiers in Immunology
IntroductionThe clinical efficacy of CAR-NK cells against CD19-expressing blood cancers has been demonstrated, and they have shown potential for treating solid tumors as well.
Xiaolan Lin, Tian Guan, Tian Guan, Yun Li, Yun Li, Yanchun Lin, Yanchun Lin, Guowei Huang, Yan Lin, Pingnan Sun, Congzhu Li, Jiang Gu, Haoyu Zeng, Haoyu Zeng, Haoyu Zeng, Haoyu Zeng, Changchun Ma, Changchun Ma, Changchun Ma, Changchun Ma   +19 more
doaj   +1 more source

The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients

Pain, 2019
Supplemental Digital Content is Available in the Text. Human sodium channel NaV1.7 in induced pluripotent stem cell–derived sensory neurons sets the action potential threshold but does not support subthreshold depolarizations.
J. Meents, E. Bressan, Stephanie Sontag, A. Foerster, P. Hautvast, Corinna Rösseler, M. Hampl, H. Schüler, Roman Goetzke, Thi Bao Chi Le, I. Kleggetveit, Kim Le Cann, Clara M Kerth, Anthony M. Rush, M. Rogers, Z. Kohl, M. Schmelz, W. Wagner, E. Jørum, B. Namer, B. Winner, M. Zenke, A. Lampert   +22 more
semanticscholar   +1 more source

Induced pluripotent stem cells: An update [PDF]

International Journal of Blood Transfusion and Immunohematology, 2015
Introduction: The discovery that the mature cells can be reprogrammed to become pluripotent increased the enormous interest in induced pluripotent stem cell (iPSC) technology for their potential application in biomedical sciences. The breakthrough research offering induction of pluripotent status in somatic cells by direct reprogramming depends upon ...
Usha Bhoria, Deepak Kumar Singh, Anubha Singh   +2 more
openaire   +1 more source