Results 71 to 80 of about 390,247 (379)
Regenerative Therapy, 2017 Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno +20 more
doaj +1 more source
Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. [PDF]
, 2013 Cells are fundamental units of life, but little is known about evolution of cell states. Induced pluripotent stem cells (iPSCs) are once differentiated cells that have been re-programmed to an embryonic stem cell-like state, providing a powerful platform
Chen, CC +5 more
core +2 more sources
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
New England Journal of Medicine, 2010 BACKGROUND Long-QT syndromes are heritable diseases associated with prolongation of the QT interval on an electrocardiogram and a high risk of sudden cardiac death due to ventricular tachyarrhythmia.
A. Moretti +13 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Failure of corneal endothelium cell monolayer is the main cause leading to corneal transplantation. Autologous cell-based therapies are required to reconstruct in vitro the cell monolayer.
Begoña M. Bosch +5 more
doaj +1 more source
Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem [PDF]
, 2009 A central unanswered question in stem cell biology, both in plants and in animals, is how the spatial organization of stem cell niches are maintained as cells move through them.
Anders +33 more
core +2 more sources
Stem Cells, 2018 There have been numerous attempts to develop stem cell transplantation approaches to promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently planning to launch a first‐in‐human clinical study of an induced pluripotent stem
Osahiko Tsuji +15 more
semanticscholar +1 more source
Proteomics in the World of Induced Pluripotent Stem Cells [PDF]
Cells, 2019 Omics approaches have significantly impacted knowledge about molecular signaling pathways driving cell function. Induced pluripotent stem cells (iPSC) have revolutionized the field of biological sciences and proteomics and, in particular, has been instrumental in identifying key elements operating during the maintenance of the pluripotent state and the
Federica Collino +7 more
openaire +5 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells. [PDF]
, 2015 Human pluripotent stem cells can in principle be used as a source of any differentiated cell type for disease modelling, drug screening, toxicology testing or cell replacement therapy.
Bredenkamp, Nicholas +2 more
core +2 more sources
Open Biology, 2018 Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological synapse structure and function, and can be either the cause or the consequence in specific pathologies.
E. Taoufik +3 more
semanticscholar +1 more source