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Induced pluripotent stem cells: An update [PDF]
International Journal of Blood Transfusion and Immunohematology, 2015 Introduction: The discovery that the mature cells can be reprogrammed to become pluripotent increased the enormous interest in induced pluripotent stem cell (iPSC) technology for their potential application in biomedical sciences. The breakthrough research offering induction of pluripotent status in somatic cells by direct reprogramming depends upon ...
Usha Bhoria +2 more
openaire +1 more source
Haematologica, 2010 Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne +13 more
doaj +1 more source
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
New England Journal of Medicine, 2010 BACKGROUND Long-QT syndromes are heritable diseases associated with prolongation of the QT interval on an electrocardiogram and a high risk of sudden cardiac death due to ventricular tachyarrhythmia.
A. Moretti +13 more
semanticscholar +1 more source
Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities [PDF]
, 2019 Three-dimensional (3D) printing of biological material, or 3D bioprinting, is a rapidly expanding field with interesting applications in tissue engineering and regenerative medicine. Bioprinters use cells and biocompatible materials as an ink (bioink) to
Rosa, Alessandro, Salaris, Federico
core +1 more source
Stem Cells, 2018 There have been numerous attempts to develop stem cell transplantation approaches to promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently planning to launch a first‐in‐human clinical study of an induced pluripotent stem
Osahiko Tsuji +15 more
semanticscholar +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Proteomics in the World of Induced Pluripotent Stem Cells [PDF]
Cells, 2019 Omics approaches have significantly impacted knowledge about molecular signaling pathways driving cell function. Induced pluripotent stem cells (iPSC) have revolutionized the field of biological sciences and proteomics and, in particular, has been instrumental in identifying key elements operating during the maintenance of the pluripotent state and the
Federica Collino +7 more
openaire +5 more sources
Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem [PDF]
, 2009 A central unanswered question in stem cell biology, both in plants and in animals, is how the spatial organization of stem cell niches are maintained as cells move through them.
Anders +33 more
core +2 more sources
Frontiers in Bioengineering and Biotechnology, 2021 Failure of corneal endothelium cell monolayer is the main cause leading to corneal transplantation. Autologous cell-based therapies are required to reconstruct in vitro the cell monolayer.
Begoña M. Bosch +5 more
doaj +1 more source
Open Biology, 2018 Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological synapse structure and function, and can be either the cause or the consequence in specific pathologies.
E. Taoufik +3 more
semanticscholar +1 more source