Results 81 to 90 of about 390,247 (379)
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities [PDF]
, 2019 Three-dimensional (3D) printing of biological material, or 3D bioprinting, is a rapidly expanding field with interesting applications in tissue engineering and regenerative medicine. Bioprinters use cells and biocompatible materials as an ink (bioink) to
Rosa, Alessandro, Salaris, Federico
core +1 more source
Scientific Reports, 2016 The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease mechanisms and drug responses.
A. Odawara +4 more
semanticscholar +1 more source
Advances in Induced Pluripotent Stem Cell Technologies [PDF]
Stem Cells International, 2012 Progress in studying induced pluripotent stem cell (iPSC) has been extremely rapid. Ever since the remarkable discovery of iPSCs by Takahashi and Yamanaka, the field has continued to evolve with exciting discoveries furthering our understanding of early development, the process of cellular reprogramming, acquisition and maintenance of pluripotency ...
Paul John Verma +4 more
openaire +3 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Stem Cells International, 2014 Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected ...
Jitong Guo +9 more
doaj +1 more source
Rats, Cats, and Elephants, but Still No Unicorn: Induced Pluripotent Stem Cells from New Species [PDF]
, 2009 SummaryTwo independent studies in this issue of Cell Stem Cell (Liao et al., 2009; Li et al., 2009) derive rat induced pluripotent stem cells (iPSCs). In one report, the method used results in rat and human iPSCs that exhibit phenotypic traits similar to
Trounson, Alan
core +1 more source
Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes
World Journal of Stem Cells, 2019 Induced pluripotent stem cells (iPSCs) were first generated by Yamanaka and colleagues over a decade ago. Since then, iPSCs have been successfully differentiated into many distinct cell types, enabling tissue-, disease-, and patient-specific in vitro ...
P. Machiraju, S. Greenway
semanticscholar +1 more source
Induced pluripotent stem cells in dentistry
Journal of Pharmacy And Bioallied Sciences, 2016 Induced pluripotent stem cells (iPSCs), a path-breaking invention, have revolutionized the regenerative medicine field. The biggest advantage of this technology is its patient-specific nature and so it is nonimmunogenic. It involves autologous tissues with limitless source of cells throughout life. The Nobel-winning concept involves the reprograming of
openaire +3 more sources
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source