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Induced Pluripotent Stem Cells
2010Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an
Zaehres, Holm +2 more
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Induced Pluripotent Stem Cells
2022A limiting factor for the identification of disease mechanisms and development of new therapies has been the access to a model system/s that can faithfully recapitulate key features of the disease and more precise clinical translations of new treatments.
Ambrin Fatima, Uzma Abdullah, Zafar Ali
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Induced Pluripotent Stem Cells
2020Progress in understanding and treatment of numerous human diseases has been hampered by the lack of representative human in vitro models, especially for diseases in which the affected cell types are difficult to obtain, such as heart diseases. Over the past decade, the use of disease affected cell types derived from induced pluripotent stem (iPS) cells
van Mil, Alain +5 more
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Livestock Induced Pluripotent Stem Cells
Reproduction in Domestic Animals, 2012ContentsChimeric animals generated from livestock‐induced pluripotent stem cells (iPSCs) have opened the door of opportunity to genetically manipulate species for the production of biomedical models, improving traits of agricultural importance and potentially providing a system to test novel iPSC therapies.
Y, Lu, J L, Mumaw, F D, West, S L, Stice
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Stem Cells, Induced Pluripotent
2021Induced pluripotent stem cells (iPSCs) refer to a type of stem cell directly generated using reprogramming techniques from multipotent adult stem cells. Therefore iPSCs gained a lower level of differentiation and could present themselves as pluripotent.
Henk ten Have +1 more
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Mouse-Induced Pluripotent Stem Cells
2012Pluripotent stem cells belong to a unique population of cells, which can self-renew indefinitely and have the potential to give rise to all cell types in an organism. Generally, pluripotent stem cells include embryonic stem cells (ESCs), embryonic germ cells (EGCs), and embryonal carcinoma cells (ECCs) (Boiani and Scholer 2005).
Hui, Zhang, Ying, Jin
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Generation of Induced Pluripotent Stem Cells
2014Induced pluripotent stem cells (iPSCs) are generated from somatic cells that have been reprogrammed by the ectopic expression of defined embryonic transcription factors. This technology has provided investigators with a powerful tool for modeling disease and developing treatments for human disorders.
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Equine Induced Pluripotent Stem Cell Culture
2023Groundbreaking work by Takahashi and Yamanaka in 2006 demonstrated that non-embryonic cells can be reprogrammed into pluripotent stem cells (PSCs) by forcing the expression of a defined set of transcription factors in culture, thus overcoming ethical concerns linked to embryonic stem cells.
Julia, Falk, F Xavier, Donadeu
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Routes to induced pluripotent stem cells
Current Opinion in Genetics & Development, 2014The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of hundreds of genes, making unique ...
Tyson Ruetz, Keisuke Kaji
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