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Induced Pluripotent Stem Cells [PDF]
, 2020 Progress in understanding and treatment of numerous human diseases has been hampered by the lack of representative human in vitro models, especially for diseases in which the affected cell types are difficult to obtain, such as heart diseases. Over the past decade, the use of disease affected cell types derived from induced pluripotent stem (iPS) cells
Pieter A. Doevendans +5 more
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Routes to induced pluripotent stem cells
Current Opinion in Genetics & Development, 2014The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of hundreds of genes, making unique ...
Tyson Ruetz, Keisuke Kaji
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Livestock Induced Pluripotent Stem Cells
Reproduction in Domestic Animals, 2012ContentsChimeric animals generated from livestock‐induced pluripotent stem cells (iPSCs) have opened the door of opportunity to genetically manipulate species for the production of biomedical models, improving traits of agricultural importance and potentially providing a system to test novel iPSC therapies.
Franklin D. West +4 more
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Mouse-Induced Pluripotent Stem Cells [PDF]
, 2012 Pluripotent stem cells belong to a unique population of cells, which can self-renew indefinitely and have the potential to give rise to all cell types in an organism. Generally, pluripotent stem cells include embryonic stem cells (ESCs), embryonic germ cells (EGCs), and embryonal carcinoma cells (ECCs) (Boiani and Scholer 2005).
Hui Zhang, Ying Jin
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Induced pluripotent stem cells: the new patient?
Nature Reviews Molecular Cell Biology, 2012Worldwide increases in life expectancy have been paralleled by a greater prevalence of chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic systems. This has not been met by commensurate development of new drugs and therapies, which is in part owing to the difficulty in modelling human diseases in laboratory ...
Bellin M. +3 more
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Clinical potential of human-induced pluripotent stem cells
Cell Biology and Toxicology, 2016The recent establishment of induced pluripotent stem (iPS) cells promises the development of autologous cell therapies for degenerative diseases, without the ethical concerns associated with human embryonic stem (ES) cells. Initially, iPS cells were generated by retroviral transduction of somatic cells with core reprogramming genes.
Dharmendra Kumar +2 more
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Generation of Induced Pluripotent Stem Cells
2014Induced pluripotent stem cells (iPSCs) are generated from somatic cells that have been reprogrammed by the ectopic expression of defined embryonic transcription factors. This technology has provided investigators with a powerful tool for modeling disease and developing treatments for human disorders.
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Generation of Induced Pluripotent Stem Cells in Rabbits
2014We describe a procedure for generating induced pluripotent stem cell lines in rabbits, using retroviral vectors expressing Oct4, Sox2, Klf4, and c-Myc of human origin to reprogram rabbit fibroblasts prepared from an ear skin biopsy. We also provide detailed procedures for characterizing the resulting iPSC lines, including the analysis of pluripotency ...
Marielle Afanassieff +5 more
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Battle for Pluripotency: Derivation of Induced Pluripotent Stem Cells
Recent Patents on Regenerative Medicine, 2011Since the first report on induced pluripotent stem (iPS) cells in 2006, iPS cells have attracted great public attention and research interest. Like embryonic stem (ES) cells, iPS cells are capable to self-renew infinitely, and maintain the developmental potential to differentiate into any types of cells in the body.
Lingyi Chen, Chunlin Mou
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Induced Pluripotent Stem Cells
The Egyptian Journal of Histology, 2011Shinya Yamanaka, Keisuke Okita
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