Results 71 to 80 of about 398,685 (377)

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis

Journal of Translational Medicine, 2015
BackgroundHuman induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-MSCs) have emerged as a promising alternative for stem cell transplantation therapy.
Jieyuan Zhang, J. Guan, X. Niu, Guo-wen Hu, Shang-Chun Guo, Qing Li, Zongping Xie, Changqing Zhang, Yang Wang   +8 more
semanticscholar   +1 more source

Proteomics in the World of Induced Pluripotent Stem Cells [PDF]

Cells, 2019
Omics approaches have significantly impacted knowledge about molecular signaling pathways driving cell function. Induced pluripotent stem cells (iPSC) have revolutionized the field of biological sciences and proteomics and, in particular, has been instrumental in identifying key elements operating during the maintenance of the pluripotent state and the
Federica Collino, Federica Collino, Rafael Soares Lindoso, Gustavo Monnerat Cahli, Adalberto Vieyra, Adriana Bastos Carvalho, Tais Hanae Kasai-Brunswick, Antonio Carlos Carvalho   +7 more
openaire   +5 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Advances in human stem cell therapies: pre-clinical studies and the outlook for central nervous system regeneration

Neural Regeneration Research, 2021
Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical settings. There are several types of stem cells currently being used for pre-clinical regenerative
Lindsey H Forbes, Melissa R Andrews
doaj   +1 more source

Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons? [PDF]

, 2013
Heart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the ...
Liao, S, Tse, HF
core   +2 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Vitamin C promotes the early reprogramming of fetal canine fibroblasts into induced pluripotent stem cells

Journal of Animal Reproduction and Biotechnology, 2023
Background: Canine induced pluripotent stem cells (iPSCs) are an attractive source for veterinary regenerative medicine, disease modeling, and drug development.
Sang Eun Kim, Jun Sung Lee, Keon Bong Oh, https://orcid.org/0000-0002-0651-0306   +3 more
doaj   +1 more source

Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts

International Journal of Molecular Sciences, 2018
Stem cells and their paracrine factors have emerged as a resource for regenerative medicine. Many studies have shown the beneficial effects of paracrine factors secreted from adult stem cells, such as exosomes, on skin aging.
M. Oh, Jinhee Lee, Y. Kim, W. Rhee, Ju Hyun Park   +4 more
semanticscholar   +1 more source

Advances in Induced Pluripotent Stem Cell Technologies [PDF]

Stem Cells International, 2012
Progress in studying induced pluripotent stem cell (iPSC) has been extremely rapid. Ever since the remarkable discovery of iPSCs by Takahashi and Yamanaka, the field has continued to evolve with exciting discoveries furthering our understanding of early development, the process of cellular reprogramming, acquisition and maintenance of pluripotency ...
Paul John Verma, Andras Dinnyes, Rajarshi Pal, Mohan C. Vemuri, Mahendra S. Rao   +4 more
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source