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Simplified detection of eosinophils in induced sputum
Inflammation Research, 2011The induction of sputum is a safe, noninvasive method of studying airway inflammation in asthma, but the method of analyzing the samples is laborious and requires well-trained technicians using highly specialized laboratory equipment. We introduce a shorter and simpler modification of the process for identifying eosinophilic inflammation from induced ...
Elizabeth, Fireman +4 more
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Induced sputum: a window to lung pathology
Biochemical Society Transactions, 2009Sputum is recognized as a sampling method for the monitoring and assessment of chronic lung diseases such as asthma, COPD (chronic obstructive pulmonary disease) and cystic fibrosis. Sputum samples the central airways and its protein components (e.g. mucins and cytokines), cellular components (e.g.
Nicholas, Ben, Djukanovic, Ratko
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Fractional exhaled nitric oxide and induced sputum
Paediatric Respiratory Reviews, 2007Conventional asthma management aimed at controlling the underlying airway inflammation is classically based on symptoms and lung function. More recently, various non invasive markers of airway inflammation have become available. The ideal measurement method should be safe, non-invasive, easy to perform, reproducible and accurate.
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INDUCED SPUTUM - TECHNICAL CONSIDERATIONS
2011During the last 15 years the use of sputum induction by inhalation of hypertonic saline solution to study the cellular and biochemical composition of the airways has been increased significantly. The induced sputum technique, which is inexpensive and does not require complex instruments, allows a relatively non-invasive sampling of airway content. Thus,
DRAGONIERI S. +3 more
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Siglec-8 in Induced Sputum of COPD Patients
2013Chronic obstructive pulmonary disease (COPD) is related to infiltration and activation of inflammatory cells in airways and pulmonary tissue. In COPD, neutrophils are prominent, while eosinophilic influx is typical to asthma. Inflammatory cells express sialic acid-binding immunoglobulin like lectins called Siglecs, a family of innate immune receptors ...
R M, Mroz +6 more
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