Results 11 to 20 of about 1,306,598 (296)

Inducible nitric oxide synthase in renal transplantation [PDF]

Kidney International, 2002
The importance of the endothelial isoform of nitric oxide synthase (eNOS) has been well established. Endothelium-derived nitric oxide has been shown to be essential for vascular homeostasis and modulation of eNOS has thus become a target in prevention of cardiovascular disease.
Joles, Jaap A., Vos, Ingrid H., Gröne, Hermann-Josef, Rabelink, Ton J.   +3 more
openaire   +3 more sources

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

Reproductive Biology and Endocrinology, 2004
Background Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric ...
Seyffarth Gunter, Nelson Paul N, Dunmore Simon J, Rodrigo Nalinda, Murphy Damian J, Carson Ray J   +5 more
doaj   +2 more sources

Inducible nitric oxide synthase and atherosclerosis [PDF]

Clinical Cardiology, 1998
AbstractNitric oxide (NO) synthase induction in vascular smooth muscle cells may play a role in local vascular injury associated with atherosclerosis or postangioplasty restenosis by inhibiting smooth muscle cell proliferation and contraction, as well as by preventing leukocyte and platelet adhesion. The expression of inducible NO synthase is increased
U, Ikeda, Y, Maeda, K, Shimada
openaire   +2 more sources

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]

, 2005
Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin, Lioté, Frédéric, Rey, Christian, Ea, Hang-Korng   +3 more
core   +1 more source

Nitric oxide synthase:non-canonical expression patterns [PDF]

, 2014
Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns ...
Anita C. Thomas, Mattila, Joshua, Mattila eJoshua, Thomas, Anita C, Mattila T Joshua, Joshuat Mattila, Joshua T. Mattila, Anita Coral Thomas, Anita C Thomas, Charles Dudley Mills, Laurel L Lenz, Klaus Ley   +11 more
core   +1 more source

Effects of NO synthase inhibitors on the synovial microcirculation in the mouse knee joint [PDF]

, 1999
Production of nitric oxide by the inducible NO synthase (iNOS) is known to be enhanced in chronic joint inflammation and osteoarthritis as well as aseptic loosening of joint prostheses.
Refior, H. J., Messmer, K., Krombach, F., Veihelmann, A.   +3 more
core   +1 more source

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. [PDF]

, 2012
All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation ...
Sabine Grüner, Ostermeier Eva, Ostermeier, Eva, Bernhard Nieswandt, Huang Paul L., Angelika Schröttle, Georg Ertl, Ertl, Georg, Ulrich Hoffmann, Peter J Kuhlencordt, Kuhlencordt Peter J., Huang, Paul, Nieswandt Bernhard, Schröttle Angelika, Grüner, Sabine, Huang, Paul L., Paul L Huang, Ponnuswamy, Padmapriya, Schröttle, Angelika, Ertl Georg, Hoffmann Ulrich, Hoffmann, Ulrich, Padmapriya Ponnuswamy, Nieswandt, Bernhard, Grüner Sabine, Ponnuswamy Padmapriya, Kuhlencordt, Peter J., Eva Ostermeier   +27 more
core   +2 more sources

Kalirin Inhibition of Inducible Nitric-oxide Synthase [PDF]

Journal of Biological Chemistry, 1999
Nitric oxide (NO) acts as a neurotransmitter. However, excess NO produced from neuronal NO synthase (nNOS) or inducible NOS (iNOS) during inflammation of the central nervous system can be neurotoxic, disrupting neurotransmitter and hormone production and killing neurons.
E A, Ratovitski, M R, Alam, R A, Quick, A, McMillan, C, Bao, C, Kozlovsky, T A, Hand, R C, Johnson, R E, Mains, B A, Eipper, C J, Lowenstein   +10 more
openaire   +2 more sources

Inducible nitric oxide synthase: An asset to neutrophils [PDF]

Journal of Leukocyte Biology, 2018
Abstract Neutrophils play a key role in innate immune responses against foreign intrusion and influence the subsequent instigation of adaptive immune response. Nitric oxide (NO) synthesized by neutrophil nitric oxide synthase (NOS) profoundly modulates their diverse physiological responsibilities furthermore encompassing pathological ...
Rashmi, Saini, Sarika, Singh
openaire   +2 more sources

Analysis of the relationship between the activity of inducible nitric oxide synthase and interleukin-1 in the pathogenesis of experimental diabetic retinopathy

Journal of Education, Health and Sport, 2020
The purpose of the study: analysis of changes in the development of hypoxia and endothelial dysfunction in experimental diabetic retinopathy. Our results indicate endothelial dysfunction and dysfunction of nitric oxide synthesis on the 30th day of ...
Ya. V. Sirman, I. V. Savytskyi
doaj   +1 more source