Results 91 to 100 of about 1,450,801 (300)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Career entry and development profile companion guide: a guide for ITT tutors and induction tutors [PDF]

, 2011
Who is the companion guide for? This guide is for initial teacher training (ITT) tutors working with trainees/teachers, and for induction tutors in schools working with newly qualified teachers (NQTs) during their induction period.

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Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure [PDF]

, 2013
Several studies have suggested that disruptions in circadian rhythms contribute to the pathophysiology of multiple psychiatric diseases, including drug addiction.
AEK Kosobud, Angela Ozburn, B Halbout, BJ Everitt, BT Hope, C Abarca, C Crosio, CA McClung, CH Ko, Colleen A. McClung, DP King, E Harms, Edgardo Falcon, EJ Nestler, EJ Nestler, EM Jones, ES Maywood, EW Lamont, FK Stephan, H Manev, JA Garcia, JA Wasielewski, JF Enwright, K Bae, Kole Roybal, LP Shearman, M Iijima, M Imbesi, M Reick, N Gekakis, R Andretic, R Spanagel, RA Wise, S Masubuchi, S Perreau-Lenz, Shibani Mukherjee, T Nikaido, T Zghoul, V Yuferov, V Yuferov, WJ Lynch, Xiaoxi Zhuang, Y Liu, Y Liu, YD Zhou, Z Travnickova-Bendova   +45 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

transient phase (induction period)

, 2014
Citation: 'transient phase (induction period)' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.T06450 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Induction of lactation in dairy heifers: milk production, inflammatory and metabolic aspects [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The aim of this study was to evaluate the metabolic, inflammatory, and hepatic aspects, as well as the milk yield in heifers submitted to protocol for induction of lactation compared to primiparous cows.
G.B. Luz, A.S. Maffi, E.G. Xavier, M.N. Correa, B.G. Gasperin, C.C. Brauner   +5 more
doaj   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Physical and Chemical Aspects of the Nucleation of Cement-Based Materials

Acta Polytechnica, 2012
A theoretical model of the nucleation of portlandite is proposed, and the critical size of a portlandite cluster and the energy barrier of nucleation are determined.
Pavel Demo, Alexey Sveshnikov, Šárka Hošková, David Ladman, Petra Tichá   +4 more
doaj  

Ethological investigation on moulting laying hens in organic farming [PDF]

, 2005
Introduction Organic egg farmers mainly rely on the same hybrids, breeding techniques and production schemes as conventional egg producers. This includes annual replacement of the laying hens.
Hirt, Helen, Zeltner, Esther
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