Results 81 to 90 of about 1,450,801 (300)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cool Air-Gas Mixtures with Combustible Gas Admixtures Steady Flameless Combustion Delay Time on Platinum Particle (Wire)

Фізика і хімія твердого тіла, 2018
The proposed work shows analytical way to find a build-up time (induction period) for a mode of steady flameless catalytic combustion on metallic wire for cool air-gas mixtures with combustible gaseous admixtures using as an example flameless combustion ...
V. V. Kalinchak, O. C. Chernenko, M. V. Sikorskyi, O. N. Sofronkov, A. V. Fedorenko   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Determination of oxidative stability in mixtures of edible oil with nonlipidic substances

Czech Journal of Food Sciences, 2001
The storage of lipid foods is mostly affected by the oxidation of lipid fraction. Dry foods are particularly sensitive because lipids are not protected by hydrated proteins against oxidation.
L. Trojáková, Z. Réblová, Z. Pokorný   +2 more
doaj   +1 more source

Exploration of flowering control in Lolium perenne L. [PDF]

, 2009
End of project reportFlowering or heading in Lolium perenne (perennial ryegrass) is induced by a period of vernalization, followed by long days at higher temperatures.
Byrne, Stephen, Donnisson, Iain, Guiney, Emma, Mur, Luis AJ   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Protoneutron star dynamos and pulsar magnetism

, 2005
We have investigated the turbulent mean-field dynamo action in protoneutron stars that are subject to convective and neutron finger instabilities during the early evolutionary phase.
A. Bonanno, Becker, Bonanno, Bonanno, Bruenn, Bruenn, Dimmelmeier, Duncan, G. Belvedere, Gil, Gil, Gil, Ginzburg, Grossman, Haberl, Kargaltsev, Keil, Keil, Miralles, Miralles, Narayan, Pavlov, Pons, Rampp, Rampp, Rüdiger, Sanwal, Thompson, Urpin, V. Urpin, Villain, Wheeler, Wheeler, Woltjer, Zwerger   +34 more
core   +1 more source

Oocyte maturation in the toad Rhinella arenarum (Amphibia, Anura): Evidence of cAMP involvement in steroid production and action [PDF]

, 2018
In this work, we describe the participation of the adenylate cyclase/3′-5′-cyclic adenonsine monophosphate (cAMP) pathway in the seasonal follicular secretion of progesterone (P 4 ) and testosterone (T), and its relationship with the maturation of ...
Arias Torres, Arias Torres, Canosa, Cerdá, Das, Deng, Eyers, Ferrell, Fortune, Gohin, Gohin, Hammes, Higashijima, Jalabert, Kamangar, Khan, Kwon, Kwon, Levin, Lin, Lin, Lubzens, Marteil, Medina, Miedlich, Nader, Nagahama, Norris, O'Brien, Pang, Pickford, Rasar, Romo, Sadler, Schuetz, Sen, Sen, Smith, Sánchez Toranzo, Sánchez Toranzo, Thomas, Voronina, Vu, White, Yamamoto, Yang, Zelarayán, Zelarayán, Zelarayán   +48 more
core   +1 more source