Results 101 to 110 of about 10,873,447 (395)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Sürtünme Karıştırma Nokta Kaynak Yönteminin Otomotiv Sektöründeki Yeri

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015
Bu çalışmada, sürtünme karıştırma nokta kaynak (SKNK) yönteminin otomotiv sektöründeki yeri incelenmiştir. SKNK, sürtünme karıştırma kaynağı (SKK) yönteminden türetilmiş ve otomotiv sektöründe oldukça dikkat çeken yeni bir kaynak yöntemidir.
Şenol MERT, Sevda MERT
doaj  

Organizational Culture: Case of the Finnish Construction Industry [PDF]

, 2018
Academic literature has long recognized the correlation between a company’s organizational culture and its quality performance. The Finnish construction industry is still a highly human powered industry, and thus, organizational culture is seen to have a
Ali-Löytty, Simo, Junnonen, Juha-Matti, Teräväinen, Ville Juhani   +2 more
core   +3 more sources

The future of manufacturing industry: a strategic roadmap toward Industry 4.0

Journal of Manufacturing Technology Management, 2018
Purpose The purpose of this paper is to conduct a state-of-the-art review of the ongoing research on the Industry 4.0 phenomenon, highlight its key design principles and technology trends, identify its architectural design and offer a strategic roadmap ...
Morteza Ghobakhloo
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Green and low carbon matters: A systematic review of the past, today, and future on sustainability supply chain management practices among manufacturing industry

, 2021
Taofeeq Durojaye Moshood, Gusman Nawanir, Fatimah Mahmud, Shahryar Sorooshian, A. Q. Adeleke   +4 more
openalex   +1 more source

Telemarketing: Five Industry Centers [PDF]

, 2006
[Excerpt] In March 2006, the 4,789 business establishments classified as telemarketing bureaus (NAICS 561422) employed 337,662 workers. Weekly wages in the industry averaged $527 and workers’ average annual pay was $24,966.
Bureau of Labor Statistics
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Deregulating the Bus Industry. [PDF]

, 1984
In its Buses White Paper, the British Government sets out its proposals for abandoning quantitative control of entry to and provision of local bus services.
Gwilliam, K.M., Mackie, P.J., Nash, C.A.
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source