Results 111 to 120 of about 685,992 (231)
Infectious disease outbreak and trade policy formulation [PDF]
This paper provides a framework to understand why a country might resort to a policy like an import ban when at risk from infectious disease outbreak overseas.
Sheikh Shahnawaz
core
Foxp3 Inhibits the Expression of HTLV-I Tax Directed from an Infectious Molecular Clone
, 2013 HEK 293T cells (5 × 105) were seeded into six-well plates 1 d prior to transfection in the absence or presence of an HTLV-I infectious molecular clone (pACH; 800 ng) and either a control (EGFP), Foxp3, or ΔFKH expression vector (800 ng).
Kazunori Fugo (55177) +8 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Microbial BiotechnologyPapaya leaf curl Guangdong virus (PaLCuGDV), a member of the genus Begomovirus, poses a significant threat to passion fruit (Passiflora edulis) cultivation. A recent field survey in the Rongjiang area of Guizhou Province revealed a high natural infection
Sheng Xu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Background Enteric infectious diseases claim more than 1 million lives annually and are among the top ten causes of death in children younger than 5 years.
GBD 2023 Diarrhoeal Disease and Enteric Infectious Diseases Collaborators +1 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Competition between the stool and BAL infectious clone derivatives.
, 2012 Vero cells, Caco-2 cells (A), and SH-SY5Y cells (B) were transfected by equimolar amounts of the stool and BAL infectious clone derivatives and virus present in the cell supernatant was analysed by sequencing post-transfection and repassage at different ...
Sandra van Belle (5648617) +9 more
core +1 more source