Results 91 to 100 of about 685,992 (231)

The 164 K, 165 K, and 167 K residues of VP1 are vital for goose parvovirus proliferation in GEFs based on PCR-based reverse genetics system

Virology Journal, 2019
Background Goose parvovirus (GPV) is the etiological agent of Derzsy’s disease and is fatal for gosling. Research on the molecular basis of GPV pathogenicity has been hampered by the lack of a reliable reverse genetics system.
Peng Liu, Liqin Yang, Jingyue Zhang, Tao Wang, Yuanyuan Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Yunya Liu, Yanling Yu, Ling Zhang, Leichang Pan, Shun Chen, Anchun Cheng   +18 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A full-length infectious cDNA clone of a dsRNA totivirus-like virus

, 2022
Totivirus-like viruses are a group of non-segmented double-stranded (ds)RNA viruses with two open reading frames, which were recently discovered and provisionally assigned to the Totiviridae family.
Okamoto, Kenta, de Matos Filipe, Diogo,, de Matos Filipe, Diogo, Okamoto, Kenta,, Wang, Han, Wang, Han,   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development of a reverse genetics system for Getah virus and characterization of rescued strains

Veterinary Research
Getah virus (GETV), a neglected and re-emerging mosquito-borne alphavirus, has become more serious and poses a potential threat to animal safety and public health.
Rongxuan Cai, Qi He, Qing Wang, Lan Tian, Zhe Chen, XiaoFeng Wu, Jiumeng Sun, Ying Shao, Xiangjun Song, Kezong Qi, Jian Tu, Zhenyu Wang   +11 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

EBioMedicine, 2017
A purified inactivated vaccine (PIV) using the Zika virus (ZIKV) Puerto Rico strain PRVABC59 showed efficacy in monkeys, and is currently in a phase I clinical trial. High-yield manufacture of this PIV is essential for its development and vaccine access.
Yujiao Yang, Chao Shan, Jing Zou, Antonio E. Muruato, Diniz Nunes Bruno, Barbosa de Almeida Medeiros Daniele, Pedro F.C. Vasconcelos, Shannan L. Rossi, Scott C. Weaver, Xuping Xie, Pei-Yong Shi   +10 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Development and Analysis of Infectious and Fluorescent Clones of Cotton Leafroll Dwarf Virus-AL

PhytoFrontiers
Cotton leafroll dwarf virus (CLRDV) is a plant viral pathogen first reported in the United States in 2017 that causes yield loss in certain cotton (Gossypium hirsutum L) cultivars but is asymptomatic in others.
Wilson C. Clark, Rachel M. Livingston, Annu Kumari, Kaylee Hirsch, J. Koebernick, S.-H. Kang, A. Price, K. N. Conner, A. Jacobson, K. M. Martin   +9 more
doaj   +1 more source