Results 211 to 220 of about 15,787 (237)

Stability of Infectious spleen and kidney necrosis virus and susceptibility to physical and chemical disinfectants

Aquaculture, 2019
Abstract The genus Megalocytivirus (MCV) includes Infectious spleen and kidney necrosis virus (ISKNV) and red seabream iridovirus (RSIV) which are listed by the World Organization for Animal Health (OIE). MCV has a broad host range and can be present as a persistent subclinical infection in some fish.
Cahya Fusianto, Paul M. Hick, Joy A. Becker   +2 more
openaire   +1 more source

A recombinant baculovirus vector vaccine (BacMCP) against the infectious spleen and kidney necrosis virus (ISKNV)

Journal of Fish Diseases, 2022
AbstractThe infectious spleen and kidney necrosis virus (ISKNV) is a highly lethal virus, which has brought significant losses to aquaculture. Therefore, a new vaccine against ISKNV with high efficiency, safety and convenience must be developed. While baculoviruses are more commonly used as protein expression systems for vaccine antigen production ...
Min Zhu, Zeen Shen, Yuchao Gu, Xinyu Tong, Yaxin Zhang, Jun Pan, Yongjie Feng, Xiaolong Hu, Yujun Wang, Guangli Cao, Renyu Xue, Chengliang Gong   +11 more
openaire   +2 more sources

Deletion of the Infectious spleen and kidney necrosis virus ORF069L reduces virulence to mandarin fish Siniperca chuatsi

Fish & Shellfish Immunology, 2019
Mandarin fish (Siniperca chuatsi) is a significant cultured species with high added value in China. With the expansion of farming, diseases of mandarin fish such as Infectious spleen and kidney necrosis virus (ISKNV) diseases are becoming more and more serious.
Yi-Fan Lin, Jian He, Ruo-Yun Zeng, Zhi-Min Li, Zhi-Yong Luo, Wei-Qiang Pan, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo He   +8 more
openaire   +2 more sources

VP15R from infectious spleen and kidney necrosis virus is a non-muscle myosin-II-binding protein

Archives of Virology, 2010
VP15R protein, encoded by the 15th open reading frame of infectious spleen and kidney necrosis virus (ISKNV), was identified. VP15R is a 263-residue protein that is first transcribed within 12 h post-infection. The VP15R mRNA is transcribed beginning at ISKNV genomic coordinate 12111, extending 167 bp upstream of the initiation codon.
Xiaopeng, Xu, Ting, Lin, Lichao, Huang, Shaoping, Weng, Wei, Wei, Zhongsheng, Li, Ling, Lü, Zhijian, Huang, Jianguo, He   +8 more
openaire   +2 more sources

ORF005L from infectious spleen and kidney necrosis virus is located in the inner mitochondrial membrane and induces apoptosis

Virus Genes, 2014
Infectious spleen and kidney necrosis virus (ISKNV) belongs to the genus Megalocytivirus in the family Iridoviridae. This virus is the etiological agent of a serious and pandemic disease in fish. Cells infected with ISKNV undergo apoptosis. In this study, the ISKNV ORF005L gene was characterized and functionally investigated.
Rui, Wang, Yang, Yi, Lihong, Liu, Yanghong, Lu, Shaoping, Weng, Jianguo, He, Xiaopeng, Xu   +6 more
openaire   +2 more sources

RING finger proteins of infectious spleen and kidney necrosis virus (ISKNV) function as ubiquitin ligase enzymes

Virus Research, 2007
Infectious spleen and kidney necrosis virus (ISKNV) is the etiological agent that causes a pandemic and severe disease in fish characteristic of enlarged and damaged spleen and kidney. To identify viral proteins involved in infection and pathogenesis, we characterized five open reading frames (ORFs) of the ISKNV genome, ORF12, ORF65, ORF66, ORF99 and ...
Junfeng, Xie, Jingyi, Zhu, Hongyan, Yang, Shaoping, Weng, Cheng, Chen, Hao, Chen, Qi, Xie, Mengfeng, Li, Jianguo, He   +8 more
openaire   +2 more sources

The roles of mandarin fish STING in innate immune defense against Infectious spleen and kidney necrosis virus infections

Fish & Shellfish Immunology, 2020
The mandarin fish Siniperca chuatsi is a cultured freshwater fish species that is popular in China because of its high market value. With the development of high-density cultural mode in mandarin fish, viral diseases such as Infectious spleen and kidney necrosis virus (ISKNV) are becoming increasingly serious.
Xiao-Wei, Qin, Jian, He, Yang, Yu, Chang, Liu, Zhi-Yong, Luo, Zhi-Min, Li, Shao-Ping, Weng, Chang-Jun, Guo, Jian-Guo, He   +8 more
openaire   +2 more sources

Molecular epidemiology and phylogenetic analysis of a marine fish infectious spleen and kidney necrosis virus-like (ISKNV-like) virus

Archives of Virology, 2006
Infectious spleen and kidney necrosis virus-like (ISKNV-like) virus causes a serious systemic disease with high morbidity and mortality of freshwater and marine fishes. Based on the ISKNV putative major capsid protein (MCP), the vascular endothelial growth factor (VEGF), the mRNA capping enzyme (Capping), and the tumor necrosis factor receptor ...
Y Q, Wang, L, Lü, S P, Weng, J N, Huang, S-M, Chan, J G, He   +5 more
openaire   +2 more sources

Optimization of the efficacy of a SWCNTs-based subunit vaccine against infectious spleen and kidney necrosis virus in mandarin fish

Fish & Shellfish Immunology, 2020
Infectious spleen and kidney necrosis virus (ISKNV) cause a high mortality disease which brings substantial economic losses to the mandarin fish culture industry in China. This study was aimed at optimizing the efficacy of a SWCNTs-based immersion subunit vaccine (SWCNTs-M-MCP) which as a promising vaccine against ISKNV.
Zhao, Zhao, Yan, Xiong, Chen, Zhang, Yi-Jun, Jia, De-Kui, Qiu, Gao-Xue, Wang, Bin, Zhu   +6 more
openaire   +2 more sources

The core ubiquitin system of mandarin fish, Siniperca chuatsi, can be utilized by infectious spleen and kidney necrosis virus

Fish & Shellfish Immunology, 2017
The process of ubiquitination regulates various cellular processes. The ubiquitin-proteasome system (UPS) in fish, which is important for the generation of innate and adaptive immune responses to pathogens, is the target of aquatic viruses to achieve immune evasion.
Runqing Huang, Jing Zhang, Guohua Zhu, Jianguo He, Junfeng Xie   +4 more
openaire   +2 more sources