Results 81 to 90 of about 225,831 (315)

Infertility.

American family physician, 2007
Infertility is defined as failure to achieve pregnancy during one year of frequent, unprotected intercourse. Evaluation generally begins after 12 months, but it can be initiated earlier if infertility is suspected based on history or if the female partner is older than 35 years.
Jose-Miller, A B, Boyden, J W, Frey, K A
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Genetic aspects of male infertility [PDF]

, 2015
Currently, infertility affects up to 140 million people worldwide. It is considered that the male factor is responsible for nearly a half of problems in obtaining pregnancy.
Bartosz Witczak, Jolanta Klusek, Justyna E. Klusek   +2 more
core   +1 more source

Infertility and Cryptorchidism [PDF]

, 2020
Cryptorchidism is a condition in which one or both of the testes become arrested somewhere along their path of migration from the posterior abdominal wall to the scrotum.
Bitran, Joshua, Simon Dadoun, Joshua Bitran, Ramasamy, Ranjith, Ranjith Ramasamy, Dadoun, Simon   +5 more
core   +1 more source

Preserving Fertility in Young Women: Triple-Step Strategy for Managing Giant Endometriomas With Minimal AMH Decline—A Case Report

Case Reports in Obstetrics and Gynecology
Endometriomas are a frequent cause of infertility in reproductive-aged women, often requiring surgery. However, cystectomy for large endometriomas may reduce ovarian reserve, as indicated by decreased anti-Müllerian hormone (AMH) levels. This case report
Arry Soryadharma, Hanom Husni Syam, Mulyanusa Amarullah Ritonga   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Biochemistry of infertility

Clinica Chimica Acta, 2020
Infertility affects approximately 186 million people worldwide and 8-12% of couples of reproductive age. Therefore, a comprehensive diagnostic evaluation of infertility is crucial to achieving improvements in targeted prevention and treatment outcomes.
T. Wasilewski, M. Łukaszewicz-Zając, J. Wasilewska, B. Mroczko   +3 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Pathophysiology, evaluation, and pharmacological treatment of infertility [PDF]

, 2019
Infertility is a disorder of the reproductive system and is defined as the inability to achieve a clinical pregnancy after 12 months of regular, unprotected sexual intercourse.
Mehra, Ruchi
core  

SOCIAL CORRELATES OF FEMALE INFERTILITY IN UZBEKISTAN [PDF]

, 2012
2012-08The purpose of this matched case-control study was to investigate the social correlates of primary infertility among females aged 35 years or less.
HARUN-OR-RASHID, MD., SAKAMOTO, JUNICHI, JUMAYEV, IZATULLA, RUSTAMOV, OYBEK, ZAKIROVA, NODIRA, KASUYA, HIDEKI   +5 more
core   +1 more source