Results 91 to 100 of about 225,831 (315)

Influence of Borderline and Pathological Sperm Morphology on Pregnancy Outcomes following Intrauterine Insemination in Pregnant Women: A Retrospective Study [PDF]

open access: yesInternational Journal of Fertility and Sterility
Background: The prognostic value of borderline and pathological sperm morphology (SM) in infertility treatmentremains unclear. This study aims to evaluate the potential impact of SM on clinical pregnancy outcomes followingintrauterine insemination (IUI ...
Roshan Nikbakht   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Health disparities and infertility: impacts of state-level insurance mandates [PDF]

open access: yes
Infertility is more common for non-Hispanic black women, non-Hispanic other race women, and Hispanic women than for non-Hispanic white women, and both infertility and impaired fecundity are more common for high school dropouts and high school graduates ...
Lucie Schmidt, Marianne Bitler
core  

Investigating Marital Relationship in Infertility: A Systematic Review of Quantitative Studies [PDF]

open access: yes, 2012
Background: Infertility is a complex issue that affects individuals and groups, and also it has serious implications for the mental and social well-being of those involved.
Coates, Rosemary   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

HIV Infection and Sexual Behaviour Among Women With Infertility in Tanzania: A Hospital-Based Study. [PDF]

open access: yes, 1997
Infertility is common in Africa, but virtually no data exist on HIV prevalence among infertile women. Mainly anthropological studies in Africa have shown that infertile women have higher risks of marital instability and possibly also have more sexual ...
Gumodoka, B   +5 more
core  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Utilization of Infertility Treatments: The Effects of Insurance Mandates [PDF]

open access: yes
Over the last several decades, both delay of childbearing and fertility problems have become increasingly common among women in developed countries. At the same time, technological changes have made many more options available to individuals experiencing
Lucie Schmidt, Marianne P. Bitler
core  

PHARMACOLOGICAL TREATMENT OF INFERTILITY [PDF]

open access: yes
This thesis explores the pharmacological treatment of female infertility, emphasizing the physiological and hormonal factors that contribute to reproductive challenges.
Hamid, Huniya
core   +2 more sources

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