Results 121 to 130 of about 119,990 (313)

Etude des différents signaux d'activation de l'inflammasome dans les monocytes/macrophages : implication dans la réponse inflammatoire vis-à-vis des nanotubes de carbone et de Leishmania infantum

, 2012
La vision de l'immunité en tant qu'entité discriminant les éléments du soi à protéger et du non soi à combattre a évolué ces dernières années avec la découverte des signaux de dangers endogènes et certains de leurs récepteurs associés.
Meunier, Etienne
core  

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Keys to NLRP3 inflammasome activation and the resulting pyroptosis from an evolutionary perspective

, 2020
The body has evolved maladaptive biochemical mechanisms to mitigate a predicted infection when it is under psychological stress. It also triggers depression or withdrawal behavior accompanied by biochemical inflammatory cascades.
Hijaz, Marwa
core  

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis

International audienceInflammasomes are multiprotein platforms that control caspase-1 activation, which process the inactive precursor forms of the inflammatory cytokines IL-1β and IL-18, leading to an inflammatory type of programmed cell death called ...
Leloup, Hubert, Huber, Anne-Laure, Oddou, Christiane, Py, Bénédicte, Monnier, Sylvain, Bardoulet, Léa, Bastien, Estelle, Ichim, Gabriel, Destaing, Olivier, Petrilli, Virginie, Nadjar, Julien, Vanbelle, Christophe   +11 more
core   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Novel perspectives on non-canonical inflammasome activation

, 2015
Catherine Emma Diamond,1,2 Hanif Javanmard Khameneh,1 David Brough,2 Alessandra Mortellaro,1 1Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore; 2Faculty of Life Sciences, University of Manchester ...
Mortellaro A, Khameneh HJ, Brough D, Diamond CE   +3 more
core  

Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

, 2018
The various symptomatic outcomes of cutaneous leishmaniasis relates to the type and potency of its underlying inflammatory responses. Presence of the cytoplasmic Leishmania RNA virus-1 (LRV1) within Leishmania guyanensis, worsens lesional inflammation ...
Prevel, Florence, Eren, Remzi O, Drexler, S.K., Eren, R.O., Beverley, S.M., Castiglioni, P., Isorce, N., Beverley, Stephen M, Remzi O. Eren, Prevel, F., Florence Prevel, Rossi, M., Matteo Rossi, Lye, L.F., Desponds, C., Mary-Anne Hartley, Hartley, Mary-Anne, Stephen M. Beverley, Nicolas Fasel, Desponds, Chantal, Rossi, Matteo, Fasel, N., Chantal Desponds, Isorce, Nathalie, Castiglioni, Patrik, Hartley, M.A., Lon-Fye Lye, Drexler, Stefan K, Stefan K. Drexler, Fasel, Nicolas, Patrik Castiglioni, Nathalie Isorce, Lye, Lon-Fye   +32 more
core   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source