Results 231 to 240 of about 190,243 (379)

High‐Specificity Spatiotemporal Cholesterol Detection by Quadrature Phase‐Shifted Polarization Stimulated Raman Imaging

Angewandte Chemie, EarlyView.
Utilizing quadrature phase modulation, the phase‐shifted polarization SRS (QP2‐SRS) microscope enables simultaneous measurement of the ρ‐related χ1111(3)$\chi _{1111}^{( 3 )}$ and χ1221(3)$\chi _{1221}^{( 3 )}$ components. In cholesterol molecular measurements, QP2‐SRS leverages the structural differences between cholesterol and other biomolecules to ...
Yongqing Zhang, Xinyu Deng, Siming Wang, Wenyu Zhou, Zhengyan Wu, Xiaobin Tang, Hyeon Jeong Lee, Delong Zhang   +7 more
wiley   +2 more sources

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Comparative analysis of short‐term and long‐term LL‐37‐induced rosacea‐like mouse models: Histopathological features and inflammatory immune responses

Animal Models and Experimental Medicine, EarlyView.
The aim of this study was to improve the long‐term LL‐37 mouse model and compare the disease manifestations and pathophysiology of short‐term and long‐term LL‐37‐induced rosacea‐like models. The results show that the long‐term LL‐37 induced mouse model provides a practical animal model for further study of the pathological mechanism of severe rosacea ...
Yiling Wu, Chuanxi Zhang, Hui Jin, Ruiping Zheng, Tian Li, Fuyu Jin, Yaqian Li, Xuemin Gao, Hong Xu, Zhongqiu Wei, Jie Yang   +10 more
wiley   +1 more source

Dysfunctional inflammasome in Schnitzler's syndrome [PDF]

, 2009
Cinzia Pizzirani, Simonetta Falzoni, Marcello Govoni, R. L. Corte, Simona Donadei, Francesco Di Virgilio, Francesco Trotta, Andrea Lo Monaco   +7 more
openalex   +1 more source

Effects of Dictyophora polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model

Animal Models and Experimental Medicine, EarlyView.
In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang, Zhihui Dai, Huanhuan Yu, Baofei Sun, Jiuyang Ding, Yuanhe Wang   +5 more
wiley   +1 more source

Expression of Nlrp1b Inflammasome Components in Human Fibroblasts Confers Susceptibility to Anthrax Lethal Toxin [PDF]

, 2009
Kuo‐Chieh Liao, Jeremy Mogridge
openalex   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

Mechanisms and Targeted Therapeutic Strategies in Sepsis-Induced Myocardial Dysfunction: The Role of NLRP3 Inflammasome-Mediated Inflammation. [PDF]

J Inflamm Res
Yu YY, Wang R, Chen GQ, Gui YF, Ma J, Ma JH, Li SJ.   +6 more
europepmc   +1 more source

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

, 2008
Annett Halle, Veit Hornung, Gabor C. Petzold, Cameron R. Stewart, Brian G. Monks, Thomas Reinheckel, Katherine A. Fitzgerald, Eicke Latz, Kathryn J. Moore, Douglas T. Golenbock   +9 more
openalex   +2 more sources

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

Animal Models and Experimental Medicine, EarlyView.
Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage, Josif Vidimce, Ryan G. Shiels, Michael Morgan, Andrew C. Bulmer   +4 more
wiley   +1 more source