Results 361 to 370 of about 197,632 (380)
Some of the next articles are maybe not open access.
2023
The innate immune response represents the first line of host defense, and it is able to detect pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) through a variety of pattern recognition receptors (PRRs). Among these PRRs, certain cytosolic receptors of the NLRs family (specifically NLRP1, NLRP3, NLRC4, and NAIP) or ...
Vinicius Nunes Cordeiro, Leal +1 more
openaire +2 more sources
The innate immune response represents the first line of host defense, and it is able to detect pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) through a variety of pattern recognition receptors (PRRs). Among these PRRs, certain cytosolic receptors of the NLRs family (specifically NLRP1, NLRP3, NLRC4, and NAIP) or ...
Vinicius Nunes Cordeiro, Leal +1 more
openaire +2 more sources
2018
The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis.
Jesús Ruiz-Cabello +2 more
openaire +3 more sources
The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis.
Jesús Ruiz-Cabello +2 more
openaire +3 more sources
2018
Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e., autoimmune diseases, cardiovascular pathologies, cancer).
Telma Miyuki Oshiro +3 more
openaire +3 more sources
Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e., autoimmune diseases, cardiovascular pathologies, cancer).
Telma Miyuki Oshiro +3 more
openaire +3 more sources
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets.
Nature reviews. Drug discovery, 2023Lieselotte Vande Walle, Mohamed Lamkanfi
semanticscholar +1 more source
2018
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases.
A. Richard Kitching +2 more
openaire +3 more sources
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases.
A. Richard Kitching +2 more
openaire +3 more sources
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases.
Nature Reviews Cardiology, 2023S. Toldo, Antonio Abbate
semanticscholar +1 more source
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Cellular & Molecular Immunology, 2023SuHyeon Oh +6 more
semanticscholar +1 more source
2011
Inflammasomes are multiprotein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the secretion of the mature forms of Caspase-1 and IL-1β from cells of the innate immune system.
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Inflammasomes are multiprotein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the secretion of the mature forms of Caspase-1 and IL-1β from cells of the innate immune system.
openaire +3 more sources
2016
Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1.
Ann M, Janowski, Fayyaz S, Sutterwala
openaire +2 more sources
Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1.
Ann M, Janowski, Fayyaz S, Sutterwala
openaire +2 more sources
A role for mitochondria in NLRP3 inflammasome activation
Nature, 2011Rongbin Zhou +3 more
semanticscholar +1 more source