Results 101 to 110 of about 90,432 (374)

The interaction of inflammasomes and gut microbiota: novel therapeutic insights

Cell Communication and Signaling
Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs).
Shirin Manshouri, Farhad Seif, Monireh Kamali, Mohammad Ali Bahar, Arshideh Mashayekh, Rasol Molatefi   +5 more
doaj   +1 more source

Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs. [PDF]

, 2009
BackgroundThe human innate immune system uses a system of extracellular Toll-like receptors (TLRs) and intracellular Nod-like receptors (NLRs) to match the appropriate level of immune response to the level of threat from the current environment.
Godzik, Adam, Istomin, Andrei Y
core   +4 more sources

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Zebrafish in Inflammasome Research [PDF]

Cells, 2019
Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge.
Gabriel Forn-Cuní, Annemarie H. Meijer, Monica Varela   +2 more
openaire   +5 more sources

Role of inflammasomes in Toxoplasma and Plasmodium infections

Parasites & Vectors
Background The detection of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by multimeric protein complexes, known as inflammasomes, triggers an inflammatory response, which is a critical component of the ...
Zhi-xin Wang, Wan-jun Jiao, Yong Yang, Hong-li Liu, Hai-long Wang   +4 more
doaj   +1 more source

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

EMBO Molecular Medicine, 2022
Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin   +16 more
doaj   +1 more source

The NLRP1 and CARD8 inflammasomes

Immunological Reviews, 2020
Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are related germline‐encoded pattern recognition receptors that form inflammasomes,
Cornelius Y. Taabazuing, A. R. Griswold, D. Bachovchin   +2 more
semanticscholar   +1 more source

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 [PDF]

, 2015
Inflammation that contributes to acute cerebrovascular disease is driven by the proinflammatory cytokine interleukin-1 and is known to exacerbate resulting injury.
Coutts, G., Cruickshank, S. M., Dénes, Ádám, Lénárt, Nikolett, Pelegrin, P.   +4 more
core   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Pyroptosis: a new insight into intestinal inflammation and cancer

Frontiers in Immunology
Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy.
Limin Chao, Wenjing Zhang, Yuchao Feng, Pei Gao, Jinyou Ma   +4 more
doaj   +1 more source