Results 111 to 120 of about 90,432 (374)
Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review
Mediators of Inflammation, 2018 Inflammasomes are multiprotein complexes that can sense pathogen-associated molecular patterns and damage-associated molecular signals. They are involved in the initiation and development of inflammation via activation of IL-1β and IL-18.
Yue Lang +6 more
doaj +1 more source
Inflammasomes in Tissue Damages and Immune Disorders After Trauma
Frontiers in Immunology, 2018 Trauma remains a leading cause of death worldwide. Hemorrhagic shock and direct injury to vital organs are responsible for early mortality whereas most delayed deaths are secondary to complex pathophysiological processes.
Perrine Bortolotti +3 more
doaj +1 more source
The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer
Biomedicines, 2021 p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key ...
Paulina Hennig +4 more
doaj +1 more source
Role of inflammasomes/pyroptosis and PANoptosis during fungal infection
PLoS Pathogens, 2021 The innate immune system is essential for recognizing foreign invaders and engaging a cellular and physiological response to control infection. Most human pathogenic fungi are opportunistic and take advantage of immune system defects.
B. Briard, R. Malireddi, T. Kanneganti
semanticscholar +1 more source
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan +12 more
wiley +1 more source
Inflammasomes contributing to inflammation in arthritis
Immunological Reviews, 2020 Inflammasomes are intracellular multiprotein signaling platforms that initiate inflammatory responses in response to pathogens and cellular damage.
L. Spel, F. Martinon
semanticscholar +1 more source
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
core +1 more source
Chronic Opioids in Gout: A Matched Cohort Study from the Veteran's Health Administration
Arthritis Care &Research, Accepted Article.Objective Though used frequently to treat flare, risk of chronic opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed chronic opioids over time.
Lindsay N. Helget +7 more
wiley +1 more source
Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]
, 2015 Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core +1 more source