Results 131 to 140 of about 90,432 (374)

Nanoparticles Decorated Nanotubes: Advanced Local Therapies From Anodized Nanoengineered Titanium Implants

Advanced Functional Materials, EarlyView.
This comprehensive review explores therapeutic titanium implants designed to enhance integration and provide superior antibacterial efficacy. It is focused on anodized titanium implants with titania nanotubes (TNTs) loaded with nanoparticles (NPs) for local therapeutic release, enhancing bioactivity and bactericidal functions.
Divya Chopra, Liwen Zhang, Tianqi Guo, Sašo Ivanovski, Ruirui Qiao, Karan Gulati   +5 more
wiley   +1 more source

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

Journal of Neuroinflammation, 2018
Background Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular location of NLRP3 inflammasome in cerebral I/R has yet come to a conclusion ...
Zhe Gong, Jingrui Pan, Qingyu Shen, Mei Li, Ying Peng   +4 more
doaj   +1 more source

Research Progress on the Role of Inflammasomes in Kidney Disease

Mediators of Inflammation, 2020
Inflammasomes are multimeric complexes composed of cytoplasmic sensors, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC or PYCARD), and procaspase-1 and play roles in regulating caspase-dependent ...
Kun Chi, Xiaodong Geng, Chao Liu, GuangYan Cai, Quan Hong   +4 more
doaj   +1 more source

Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation [PDF]

, 2016
Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis-associated inflammation. This study aims to assess in acute coronary syndrome (ACS) patients (
Christina Bursill, Cloe A Payet, David S Celermajer, Gonzalo J Martínez, Jennifer Y Barraclough, Sanjay Patel, Stacy Robertson, † ‡, † ‡   +8 more
core   +1 more source

Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies

Advanced Healthcare Materials, EarlyView.
PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall, Safaa Naiel, Quan Zhou, Pareesa Ali, Tamana Rubina Yousof, Emily Wong, Ricardo Couto, Byron Yépez, Bernhard Seifried, Paul Moquin, Rod Rhem, Myrna Dolovich, Martin Rainer Kolb, Kjetil Ask, Todd Hoare   +14 more
wiley   +1 more source

Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome

Frontiers in Immunology, 2020
Context and Objectives: Inflammation is the leading mechanism involved in both physiological and pathological rupture of fetal membranes. Our aim was to obtain a better characterization of the inflammasome-dependent inflammation processes in these ...
Marilyne Lavergne, Corinne Belville, Héléna Choltus, Christelle Gross, Régine Minet-Quinard, Régine Minet-Quinard, Denis Gallot, Denis Gallot, Vincent Sapin, Vincent Sapin, Loïc Blanchon   +10 more
doaj   +1 more source

Inflammatory caspases : key regulators of inflammation and cell death [PDF]

, 2014
The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel, Lamkanfi, Mohamed   +1 more
core   +2 more sources

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly [PDF]

, 2016
Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. This leads to secretion of proinflammatory cytokines and pyroptosis.
Adams, Aida, Alvin Lu, Antonin, Arora, Ashour, Barrios-Rodiles, Broz, Broz, Burg, Cai, Catherine Tang, Chakrabarti, Chen, Conrath, de Alba, Delaloye, Doxsey, Emsley, Fernandes-Alnemri, Ferrao, Florian I. Schmidt, Guimaraes, Hamers-Casterman, Hao Wu, Hauenstein, Helma, Hidde L. Ploegh, Hornung, Hu, Irannejad, Jakobs, Jeff W. Chen, Jianbin Ruan, Kagan, Kirchhofer, Kortmann, Lechtenberg, Lin, Lu, Maass, Man, Masumoto, Masumoto, Meerbrey, Milne, Muyldermans, Paalanen, Pardon, Sahillioglu, Sborgi, Shenoy, Sosa, Taipale, Vanaja, Vance, Wu, Wu, Yang, Young, Zhang   +60 more
core   +1 more source

Guides for Developing Hundreds of Novel Chiral MXenes and MBenes Nanosheets/Quantum Dots for Next‐Generation Chiral Engineered Biomaterials Applications

Advanced Healthcare Materials, EarlyView.
The emerging field of MXene/MBene materials has progressed rapidly, advancing diverse research fields, including biomedical engineering, biomedicine, agriculture, and the environment. This nanobiotechnology can tackle longstanding challenges in these areas.
Alireza Rafieerad, Ahmad Amiri
wiley   +1 more source