Results 141 to 150 of about 90,432 (374)

Bacterial exotoxins and the inflammasome

Frontiers in Immunology, 2015
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.
Allison J. Greaney, Stephen H. Leppla, Mahtab eMoayeri   +2 more
doaj   +1 more source

Lipids, inflammasomes, metabolism, and disease

Immunological Reviews, 2020
Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death, pyroptosis.
P. Anand
semanticscholar   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, EarlyView.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets

Journal of Neuroinflammation, 2020
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS.
Vaidya Govindarajan, J. P. de Rivero Vaccari, R. Keane   +2 more
semanticscholar   +1 more source

Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics

Advanced Materials, EarlyView.
This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding, Wenhao Li, Ling Mei, Suling Luo, Jing Tao, Chongxiu Shi, Hongping Yang, Wei Feng, Yungchang Chen, Yu Chen, Jong Seung Kim, Xue Shen   +11 more
wiley   +1 more source

Inflammasomes and Atherosclerosis

Cardiovascular Innovations and Applications, 2016
Inflammation plays an important role in atherosclerosis. Inflammasomes play a crucial role in innate immunity, which mediates the body’s response to various pathogens. Of the different types of inflammasomes, NLRP3 has been implicated in atherosclerosis through the production of proinflammatory cytokines, IL-1β and IL-18. This review describes the role
Yao Dai, J. L. Mehta, S. Vallurupalli
openaire   +3 more sources

Reactive Oxygen Species Interact With NLRP3 Inflammasomes and Are Involved in the Inflammation of Sepsis: From Mechanism to Treatment of Progression

Frontiers in Physiology, 2020
Over the past 10 years, the crisis of sepsis has remained a great challenge. According to data from 2016, the sepsis-related mortality rate remains high.
Shuai Zhao, Fan Chen, Qiliang Yin, Dunwei Wang, W. Han, Yuan Zhang   +5 more
semanticscholar   +1 more source

Quantitative Assessment of Gut and Vascular Barriers in TTOP, a Cartridge‐Based Bicompartmental Culture Platform

Advanced Materials Technologies, EarlyView.
The modular, versatile, and standardized cartridge‐based culture module allows to replicate gut and vascular barriers. Its conventional handling requirements facilitate adoption by non‐technical users, while the design allows safe manipulation and retrieval of samples for permeability assays and endpoint analysis.
Lorenzo Pietro Coppadoro, Maria Lombardi, Sabrina Nicolò, Alessandra Maria Anna Rando, Gianfranco Beniamino Fiore, Chiara Foglieni, Monica Soncini   +6 more
wiley   +1 more source

Safe‐and‐Sustainable‐by‐Design Approach and Decision Support System for Advanced Materials

Advanced Sustainable Systems, EarlyView.
The HARMLESS Safe‐and‐Sustainable‐by‐Design (SSbD) approach and SSbD‐Decision Support System (DSS) guide designers through a workflow of three tools providing design and assessment advice. By adapting the data and resource requirements to each innovation stage, the SSbD‐DSS facilitates practical implementation of SSbD, supporting the user to find a ...
Susan Dekkers, Veronique Adam, Veronica Di Battista, Andrea Haase, Julia Prinz, Gregor Nagel, Wouter Fransman, Michael Persson, Blanca Suarez‐Merino, Wendel Wohlleben, Otmar Schmid, Eugene Van Someren   +11 more
wiley   +1 more source