Results 341 to 350 of about 90,432 (374)
The Role of the Tumor Microenvironment (TME) in Advancing Cancer Therapies: Immune System Interactions, Tumor-Infiltrating Lymphocytes (TILs), and the Role of Exosomes and Inflammasomes. [PDF]
Int J Mol SciErasha AM +4 more
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Inflammasomes: mechanism of assembly, regulation and signalling
Nature Reviews Immunology, 2016Petr Broz, Vishva M Dixit
exaly +2 more sources
Inflammasomes and adaptive immune responses
Nature Immunology, 2021Russell E Vance
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The Inflammasomes: Guardians of the Body
Annual Review of Immunology, 2009Fabio Martinon
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Inflammasomes in neurological disorders — mechanisms and therapeutic potential
Nature Reviews NeurologyKishore Aravind Ravichandran +1 more
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Nature Reviews Neuroscience, 2014
Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1
John G Walsh +2 more
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Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1
John G Walsh +2 more
exaly +4 more sources
Molecular Aspects of Medicine, 2022
Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
openaire +3 more sources
Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
openaire +3 more sources
Developmental & Comparative Immunology, 2021
Since inflammasomes were discovered in the early 21st century, knowledge about their biology has multiplied exponentially. These cytosolic multiprotein complexes alert the immune system about the presence of infection or tissue damage, and regulate the subsequent inflammatory responses.
Victoriano Mulero +2 more
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Since inflammasomes were discovered in the early 21st century, knowledge about their biology has multiplied exponentially. These cytosolic multiprotein complexes alert the immune system about the presence of infection or tissue damage, and regulate the subsequent inflammatory responses.
Victoriano Mulero +2 more
openaire +3 more sources
The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation
Science immunology, 2021Radiation activates AIM2 and NLRP3 inflammasomes to enhance IL-1 signaling on DCs, leading to antitumor immunity. Radiation needs the inflammasome The inflammasome is a multiprotein complex that is activated in response to pathogen and danger-associated ...
Chuanhui Han +8 more
semanticscholar +1 more source