Results 91 to 100 of about 305 (109)

Inflammasomopathies: mechanisms and disease signatures

Trends in Immunology
Inflammasomes form in response to infection, cellular stress, or damage. Gain-of-function (GOF) mutations in inflammasome receptors have been identified as the underlying cause of severe inflammatory diseases, termed 'inflammasomopathies'. Recently, molecular interrogation of these diseases revealed several distinctions at the level of the tissue ...
Fiachra Humphries
exaly   +3 more sources

Inflammasomopathies: Diseases Linked to the NLRP3 Inflammasome

2012
Dominic De Nardo, Larisa I Labzin, Eicke Latz   +2 more
exaly   +4 more sources

DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling

Science Immunology, 2022
Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it affects inflammasome regulation in vivo is not yet established. Here, we report three families with immune-associated defects, poor growth, pancytopenia, and skin pigmentation abnormalities that segregate with biallelic DPP9
Cassandra R. Harapas, Kim S. Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Rass-Rothschild, Bertrand Boisson, Scott B. Drutman, Pawat Laohamonthonkul, Devon Bonner, Jingwei Rachel Xiong, Mark D. Gorrell, Sophia Davidson, Chien-Hsiung Yu, Mark D. Fleming, Jonas Gudera, Jerry Stein, Miriam Ben-Harosh, Emily Groopman, Akiko Shimamura, Hannah Tamary, Hülya Kayserili, Nevin Hatipoğlu, Jean-Laurent Casanova, Jonathan A. Bernstein, Franklin L. Zhong, Seth L. Masters, Bruno Reversade   +28 more
openaire   +3 more sources

Is Alzheimer’s disease an inflammasomopathy?

Ageing Research Reviews, 2019
Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progression of AD. In the last few years
Claudia F, Pereira, Armanda E, Santos, Paula I, Moreira, Ana Catarina, Pereira, Fabio J, Sousa, Sandra M, Cardoso, M Teresa, Cruz   +6 more
openaire   +2 more sources

[Analysis of clinical characteristics of 35 inflammasomopathies cases].

Zhonghua er ke za zhi = Chinese journal of pediatrics, 2022
Objective: To summarize the clinical characteristics of inflammasomopathies, enhance the recognition of those diseases, and help to establish the early diagnosis. Methods: The clinical manifestations including fever, rash, systems involvement as well as laboratory results and genotypic characteristics of 35 children with inflammasomopathies diagnosed ...
M S, Ma, W, Wang, Y, Zhou, L Q, Zhong, Z X, Yu, L J, Gou, J, Li, L, Wang, C Y, Wang, X Y, Tang, M Y, Quan, H M, Song   +11 more
openaire   +1 more source

The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy

Toxicology and Applied Pharmacology, 2020
The antimalarial drug artesunate (Art) has proven its beneficial effects against ischemia/reperfusion (I/R) injury in diverse organs, but its potential role against hepatic I/R is still obscure. This study, hence, examined whether treatment with Art alone or in combination with rapamycin (Rapa), an mTOR inhibitor, can ameliorate hepatic I/R injury via ...
Mai El-Sayed, Ghoneim, Dalaal M, Abdallah, Abdelhadi Mohamed, Shebl, Hanan S, El-Abhar   +3 more
openaire   +2 more sources

Sunset Yellow dye effects on gut microbiota, intestinal integrity, and the induction of inflammasomopathy with pyroptotic signaling in male Wistar rats

Food and Chemical Toxicology
Although concern persists regarding possible adverse effects of consumption of synthetic azo food dyes, the mechanisms of any such effects remain unclear. We have tested the hypothesis that chronic consumption of the food dye Sunset Yellow (SY) perturbs the composition of the gut microbiota and alters gut integrity.
Sara Ahmed Zahran, Suzan Mohamed Mansour, Amal Emad Ali, Shady Mansour Kamal, Ute Römling, Hanan Salah El-Abhar, Marwa Ali-Tammam   +6 more
openaire   +2 more sources

A comparative analysis of inflammasomopathy and interferonopathy in vaccine myocarditis and conventional myocarditis 3512

The Journal of Immunology
Abstract Description   Myocarditis can be triggered by viral infections and mRNA COVID-19 vaccines. While vaccine-associated myocarditis(VAM) shows better outcomes than conventional myocarditis(COM), its mechanisms remain poorly understood.
Yongjae Lee, Junho Hyun, Eui-Soon Kim, Jeong Ho Joo, Jungyu Kim, Eui-Cheol Shin, Jong-Chan Youn, Sang Eun Lee, Jeong Seok Lee   +8 more
openaire   +1 more source

Cutaneous signs and mechanisms of inflammasomopathies

Annals of the Rheumatic Diseases, 2022
Carina Borst, Dorte Symmank, Wolfgang J Weninger   +2 more
exaly  

NLRC4 inflammasomopathy with spondyloarthritis and a complete response to TNF inhibition

The Journal of Allergy and Clinical Immunology: In Practice, 2019
Mathijs Willemsen, Myrurgia Abdul-Hamid, Thea H.M. Schoonbrood   +2 more
openaire   +1 more source