Results 11 to 20 of about 305 (109)

Human Autoinflammatory Diseases Mediated by NLRP3-, Pyrin-, NLRP1-, and NLRC4-Inflammasome Dysregulation Updates on Diagnosis, Treatment, and the Respective Roles of IL-1 and IL-18

Frontiers in Immunology, 2020
Recent research has led to novel findings in inflammasome biology and genetics that altered the diagnosis and management of patients with autoinflammatory syndromes caused by NLRP3-, Pyrin-, NLRP1-, and NLRC4-inflammasomes and spurred the development of ...
Sara Alehashemi, Raphaela Goldbach-Mansky, Alehashemi Sara   +2 more
exaly   +3 more sources

Single-Center Overview of Pediatric Monogenic Autoinflammatory Diseases in the Past Decade: A Summary and Beyond [PDF]

Frontiers in Immunology, 2020
Objective: Monogenic autoinflammatory diseases (AIDs) are inborn disorders caused by innate immunity dysregulation and characterized by robust autoinflammation.
Wei Wang, Zhongxun Yu, Lijuan Gou, Linqing Zhong, Ji Li, Mingsheng Ma, Changyan Wang, Yu Zhou, Ying Ru, Zhixing Sun, Qijiao Wei, Yanqing Dong, Hongmei Song   +12 more
doaj   +2 more sources

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases. [PDF]

Microbiol Immunol
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Zhang T, Toyomoto T, Sawa T, Akaike T, Matsunaga T.   +4 more
europepmc   +2 more sources

Monogenic Autoinflammatory Diseases: State of the Art and Future Perspectives [PDF]

International Journal of Molecular Sciences, 2021
Giulia Di Donato, Luciana Breda, Francesco Chiarelli   +2 more
exaly   +2 more sources

Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy [PDF]

Open Forum Infectious Diseases, 2021
Abstract The effect of autoinflammatory diseases on severe acute respiratory syndrome coronavirus 2 infection remains unknown. We report a case of coronavirus disease 2019 (COVID-19) in a patient with autoinflammation with infantile enterocolitis with inflammatory flares due to a mutation in the inflammasome component NLRC4.
Jeffrey K Duncan-Lowey, Vaidehi Chowdhary, Dana W Dunne   +2 more
openaire   +2 more sources

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy [PDF]

Journal of Allergy and Clinical Immunology, 2019
BACKGROUND: CCAAT enhancer-binding protein epsilon (C/EBPε) is a transcription factor involved in late myeloid lineage differentiation and cellular function. The only previously known disorder linked to C/EBPε is autosomal recessive neutrophil-specific granule deficiency leading to severely impaired neutrophil function and early mortality.
Goos H., Fogarty C. L., Sahu B., Plagnol V., Rajamaki K., Nurmi K., Liu X., Einarsdottir E., Jouppila A., Pettersson T., Vihinen H., Krjutskov K., Saavalainen P., Jarvinen A., Muurinen M., Greco D., Scala G., Curtis J., Nordstrom D., Flaumenhaft R., Vaarala O., Kovanen P. E., Keskitalo S., Ranki A., Kere J., Lehto M., Notarangelo L. D., Nejentsev S., Eklund K. K., Varjosalo M., Taipale J., Seppanen M. R. J.   +31 more
openaire   +6 more sources

Therapeutic potential of targeting interleukin‐1 family cytokines in chronic inflammatory skin diseases*

British Journal of Dermatology, Volume 186, Issue 6, Page 925-941, June 2022., 2022
Plain language summary available online Summary The interleukin (IL)‐1 family of cytokines is a central regulator of a myriad of immunological responses. It comprises several cytokines, including those belonging to the IL‐1, IL‐36 and IL‐18 subfamilies, as well as IL‐33.
Laura Calabrese, Zeno Fiocco, Takashi K. Satoh, Ketty Peris, Lars E. French   +4 more
wiley   +1 more source

First Description of Late‐Onset Autoinflammatory Disease Due to Somatic NLRC4 Mosaicism

Arthritis &Rheumatology, Volume 74, Issue 4, Page 692-699, April 2022., 2022
Objective Autoinflammatory diseases are inherited disorders of innate immunity that usually start during childhood. However, several recent reports have described an increasing number of patients with autoinflammatory disease starting in adulthood. This study was undertaken to investigate the underlying cause of a case of late‐onset uncharacterized ...
Daniela Ionescu, Alejandro Peñín‐Franch, Anna Mensa‐Vilaró, Paola Castillo, Laura Hurtado‐Navarro, Cristina Molina‐López, Silvia Romero‐Chala, Susana Plaza, Virginia Fabregat, Segundo Buján, Joana Marques, Ferran Casals, Jordi Yagüe, Baldomero Oliva, Luis Miguel Fernández‐Pereira, Pablo Pelegrín, Juan I. Aróstegui   +16 more
wiley   +1 more source

Artesunate relieves acute kidney injury through inhibiting macrophagic Mincle‐mediated necroptosis and inflammation to tubular epithelial cell

Journal of Cellular and Molecular Medicine, Volume 25, Issue 18, Page 8775-8788, September 2021., 2021
Abstract Artesunate is a widely used derivative of artemisinin for malaria. Recent researches have shown that artesunate has a significant anti‐inflammatory effect on many diseases. However, its effect on acute kidney injury with a significant inflammatory response is not clear. In this study, we established a cisplatin‐induced AKI mouse model and a co‐
Xian‐ying Lei, Rui‐zhi Tan, Jian Jia, Song‐lin Wu, Cheng‐li Wen, Xiao Lin, Huan Wang, Zhang‐jing Shi, Bo Li, Yan Kang, Li Wang   +10 more
wiley   +1 more source

Novel Majeed Syndrome–Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis

Arthritis &Rheumatology, Volume 73, Issue 6, Page 1021-1032, June 2021., 2021
Objective To identify novel heterozygous LPIN2 mutations in a patient with Majeed syndrome and characterize the pathomechanisms that lead to the development of sterile osteomyelitis. Methods Targeted genetic analysis and functional studies assessing monocyte responses, macrophage differentiation, and osteoclastogenesis were conducted to compare the ...
Farzana Bhuyan, Adriana A. de Jesus, Jacob Mitchell, Evgenia Leikina, Rachel VanTries, Ronit Herzog, Karen B. Onel, Andrew Oler, Gina A. Montealegre Sanchez, Kim A. Johnson, Lena Bichell, Bernadette Marrero, Luis Fernandez De Castro, Yan Huang, Katherine R. Calvo, Michael T. Collins, Sundar Ganesan, Leonid V. Chernomordik, Polly J. Ferguson, Raphaela Goldbach‐Mansky   +19 more
wiley   +1 more source