Results 51 to 60 of about 4,758,008 (341)

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis? [PDF]

, 2018
Indexación: Scopus.Papillary thyroid cancer (PTC) is the most prevalent endocrine neoplasia. The increased incidence of PTC in patients with thyroiditis and the frequent immune infiltrate found in PTC suggest that inflammation might be a risk factor for ...
Aggarwal, Akaike, Antonelli, Aoki, Balkwill, Balkwill, Balkwill, Ben-Baruch, Ben-Baruch, Ben-Baruch, Bentrem, Bikfalvi, Bressan, Carini, Caux, Cerutti, Chen, Chiovato, Clark, Evers, Fagin, Fallahi, Fallahi, Fallahi, Ferrannini, Fugazzola, Fulton, Giovannone, Harris, Haugen, Huang, Ichikawa, Ishikura, Keane, Keane, Khodarev, Kim, Lai, Lazebnik, Liao, Loetscher, Maggi, Mak, Mantovani, Mantovani, Marazuela, Marone, Matrisian, Matthys, McEvoy, Melillo, Melillo, Melillo, Melillo, Miccoli, Moser, Moser, Nagawa, Negri, Okayasu, Oppenheim, Pal, Pal, Pal, Paloyan, Paloyan, Peled, Peng, Pfaffl, Potlukova, Richmond, Richmond, Rizzoli, Rollins, Romagnani, Rothstein, Santoro, Serio, Serio, Shah, Shaha, Sonoo, Sorensen, Strieter, Strieter, Strieter, Sun, Taketo, Teixido, Toniolo, Tuttle, Vigneri, Ward, Ward, Ward, Welch, Wells, Wells, Wells, Wilhelm, Wu, Wynford-Thomas, Yang, Yeo, Zhang   +104 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy

Journal of Immunology Research, 2023
The altered expression of ARMCX1 in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled.
Changheng Lv, Di Yang, Donghu Zhang, Jiajia Shen, Zechen Wang, Siyuan He, Lingzhang Meng, Jian Song, Jingjie Zhao   +8 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Smac-mimetics reduce numbers and viability of human osteoclasts

Cell Death Discovery, 2021
Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis.
Ingrid Nyhus Moen, Marita Westhrin, Erling Håland, Markus Haug, Unni Nonstad, Merisa Klaharn, Therese Standal, Kristian K. Starheim   +7 more
doaj   +1 more source

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]

, 2018
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro, García Domínguez, Irene, García Revilla, Juan, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Santiago Pavón, Martiniano, Venero Recio, José Luis, Veselá, Karolina   +7 more
core   +3 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

The Expression and Regulation of Chemokines (CXCL9, CXCL10, CXCL11) in Urinary Bladder Inflammation of the Mouse [PDF]

, 2017
Interstitial cystitis is a serious chronic condition that causes bladder pain and increased voiding frequency in millions of adults in the US, most of them women.
Guo, Michael
core   +1 more source